Project Grant K99DA065878
- Federal Grant Award Summary The Medical University of South Carolina received a $2.01 million Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning June 1, 2025, and concluding February 28, 2030. The award funds basic neuroscience research investigating the neural circuit mechanisms underlying opioid and alcohol use disorders, specifically examining how brain circuits prioritize drug-seeking behaviors over natural...
- Federal Project Grant Award Summary The Medical University of South Carolina received a $415,250 Project Grant award effective July 1, 2025, through June 30, 2027, from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research investigating the role of cortical astroglia in heroin seeking behaviors, utilizing advanced neuroimaging techniques including genetic calcium indicators and two-photon imaging to analyze neuronal...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Medical University of South Carolina a Project Grant totaling $187,984 under the Drug Use and Addiction Research Programs (CFDA 93.279) on October 10, 2025, with a completion date of April 30, 2028. This award supports research investigating the therapeutic potential of psilocybin in addressing stress-cued reinstatement and relapse behavior in opioid use disorder (OUD) patients, with particular focus on...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $159,615 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2025, for research extending through June 30, 2027. This K99/R00 award supports a research initiative titled "Predicting Craving and Relapse Using Neurobehavioral Markers of Goals and Habits in Opioid Use Disorder." The project delivers longitudinal neurobehavioral...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded the University of Pittsburgh a $198,164 Project Grant on September 25, 2025, to support basic neuroscience research investigating delta opioid receptor (DOR) regulation in the prefrontal cortex and its relationship to opioid use disorder (OUD) and oxycodone-related behavioral outcomes. The research will be conducted in Pittsburgh, Pennsylvania,...
- Federal Grant Award Summary The University of Southern California received a $108,000 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded February 15, 2026, with completion targeted for January 31, 2028. This research project investigates the molecular mechanisms of a kappa opioid receptor (KOR) selective negative allosteric modulator (NAM) to address critical gaps in understanding KOR signaling and...
- Federal Grant Award Summary The Medical University of South Carolina received a $2.69 million Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 1, 2025, with completion scheduled for February 28, 2030. This research initiative examines how social functioning changes during opioid use disorder (OUD) treatment and its association with positive treatment outcomes. The study combines Ecological Momentary...
- This project grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports fundamental neuroscience research investigating the neural mechanisms linking stress exposure to opioid use disorder initiation. The University of South Carolina received $192,149 to conduct a two-year research project (February 1, 2026 through January 31, 2028) examining noradrenergic circuit mechanisms in stress-induced opioid-seeking behavior....
- Federal Project Grant Award Summary The Medical University of South Carolina received a $182,249 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) effective July 15, 2025, through June 30, 2029. This award supports the implementation and evaluation of EMPWR (Empowering Pregnant Women Receiving Medications for Opioid Use Disorder), a digitally enhanced intervention designed to improve buprenorphine treatment retention among...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $787,594 Project Grant on September 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a five-year research initiative examining the cortical mechanisms of opioid reinforcement and opioid use disorder (OUD). The research program delivers comprehensive neuroscience research services focused on understanding how mu opioid receptors...
The National Institute on Drug Abuse (NIDA) awarded a Project Grant of $210,168 to The Medical University of South Carolina under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period May 1, 2026 through April 30, 2028. The award supports research to dissect glutamatergic pathway-specific neural ensembles that guide motivated behavior and drive opioid use disorder (OUD) relapse. The research employs two-photon calcium imaging and neuroscience methodologies to investigate how heroin use adapts excitatory circuitry governing reward-seeking behavior, with specific focus on the glutamatergic pathway from the paraventricular thalamus to the nucleus accumbens shell. The grant is structured as a K99/R00 career development mechanism supporting an independent investigator beginning their research program. This award will advance fundamental understanding of the neural circuit adaptations underlying habitual heroin use and lack of inhibitory control characteristic of OUD, with the objective of identifying pathway-specific circuit elements and treatment strategies to prevent relapse. The research conducted at MUSC's Charleston, South Carolina facility will generate new knowledge on the spatiotemporal dynamics of drug-naive and drug-experienced glutamatergic networks, contributing to NIDA's broader portfolio of basic and translational research addressing substance use, addiction, and related health outcomes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $210.2k | 4/17/26 |