This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the NIH's Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $751,043 research project at the University of Massachusetts Medical School focused on investigating the cellular and molecular mechanisms underlying the complex co-morbidity of opioid use disorder (OUD), major depressive disorder (MDD), and HIV in the human brain. The project will leverage single-cell sequencing technologies and other...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $562,014 to the University of California, San Diego (UCSD) for a project titled "Opioid Actions on the Habenulo-Peduncular Circuit". The project aims to investigate the role of the medial habenula and interpeduncular nucleus in mediating the aversive qualities of opioid dependence and withdrawal, using a combination of molecular,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the CFDA program "Drug Use and Addiction Research Programs" (93.279), will support research to uncover the neurophysiological signatures within the addiction circuitry related to acute opioid use. The $159,711 award, effective January 1, 2025 through December 31, 2029, will leverage a unique ability to directly record local field potentials from awake humans with implanted brain electrodes. This will...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $445,500.00 to the University of Alabama at Birmingham (UAB) to conduct high-throughput identification and characterization of conserved regulators of drug-induced plasticity in the Caenorhabditis elegans nervous system. The goal is to generate comprehensive molecular, behavioral, and neuronal activity atlases in response to acute and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $903,965 to the University of Alabama at Birmingham (UAB) to conduct research on prefrontal cortex circuits that control heroin seeking behavior. The goal is to determine if the recruitment of a specific prefrontal cortex circuit that drives heroin seeking is a hallmark of opioid use disorder (OUD) pathology, whether this circuit engages a...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,251 to The Trustees of the University of Pennsylvania to develop a novel "released markers of activity" (RMAs) blood-based monitoring system for long-term tracking of neural circuit activity and opioid receptor gene expression changes in mice exposed to opioids. The goal is to better understand the molecular and functional...
This $403,542 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to profile projection-specific proteome associated with the incubation of oxycodone craving. The project will focus on the orbitofrontal cortex (OFC) to dorsal striatum (DS) projections, analyzing proteome changes in OFC neuronal somas (Aim 1) and OFC-DS projection-specific synaptoneurosomes in the DS (Aim 2) during the incubation of oxycodone...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...