The National Institute on Drug Abuse (NIDA) awarded a $818,513 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the Regents of the University of Minnesota to investigate the role of dopamine signaling in the basolateral amygdala in regulating individual differences in reward-based learning strategies and addiction-like behaviors. The 5-year grant, which commenced on Sep 15, 2024, will focus on examining how individual differences in Pavlovian reward learning approaches...
The National Institute on Drug Abuse (NIDA) awarded a $135,765 project grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Washington to investigate the role of corticotropin-releasing factor (CRF) in modulating accumbal dopamine and producing escalation of drug intake. The research aims to 1) test the necessity of CRF receptor 1 in the nucleus accumbens (NAc) for the escalation of drug taking, and 2) examine the modulation of phasic dopamine response...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This federal Project Grant award of $811,112 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research by the University of California, San Francisco (UCSF) to investigate the brain networks and neural signaling mechanisms that underlie sudden "insight" learning of cue-reward associations. The key objectives are to use advanced techniques like two-photon calcium imaging, high-density...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,076,036 to the University of Pittsburgh to conduct research on targeting prefrontal cortex (PFC) interneurons for personalized treatments in opioid use disorder (OUD). The key objectives are to: Assess how individual differences in PFC theta power and interneuron physiology correlate with fentanyl self-administration and affective disturbances...
This Project Grant award of $250,568.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a 3-year research project to investigate the neurobiological mechanisms underlying individual and sex differences in emotional cue processing related to addiction and post-traumatic stress disorder. The award recipient, the Regents of the University of Michigan, will use chemogenetic and fiber photometry techniques to gain control...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $2,075,613 research project conducted by the Regents of the University of Michigan. The project aims to validate a human sign-/goal-tracking paradigm and identify neurobehavioral signatures of sign- and goal-tracking behaviors in emerging adults, which are key to understanding individual differences in addiction liability. The...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $139,927 to the University of Washington to assess the impact of chronic, voluntary fentanyl intake on gene expression and neural activity patterns in the brain. The key objectives are to: 1) conduct single-cell RNA sequencing in the nucleus accumbens to analyze changes in gene expression after chronic fentanyl use and withdrawal, and 2)...
This federal Project Grant award, identified as K99DA062328, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant, totaling $148,403.00, is funding research at the University of Washington to investigate the role of the basolateral amygdala in assessing environmental stimuli and encoding avoidance behavior. The 2-year project aims to: 1) determine how functional antagonism of valence-selective neuronal ensembles...