This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,785,632.00 over a 5-year period starting on July 15, 2024 to the University of Pittsburgh. The award will support research aimed at elucidating the role of astrocytic dopamine signaling in the nucleus accumbens and its impact on cue-conditioned motivated behaviors and cocaine relapse. The key objectives include characterizing the...
This $180,646 Project Grant award, issued by the National Institute on Drug Abuse (NIDA) under the Federal Grant Program CFDA 93.279 - Drug Use and Addiction Research Programs, will support research to investigate the molecular mechanisms underlying astrocytic CREB's regulation of cocaine drug-seeking behavior. The research, to be conducted at the Icahn School of Medicine at Mount Sinai, aims to elucidate the astrocyte transcriptome and its epigenetic regulation in the context of drug addiction....
This $613,107 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a research project titled "Analyzing Brain-Wide Bases of Neuroplastic Change Using New Imaging Tools." The Massachusetts Institute of Technology (MIT) is the primary awardee for this project, which aims to apply a novel bioluminescence-based imaging method called BLUSH to study the spatiotemporal relationships between neural...
The federal Project Grant award R01DA061766 for $428,194.00, awarded on April 1, 2025 by the National Institute on Drug Abuse (NIDA), supports research to understand the role of prefrontal cortex circuits in controlling heroin-seeking behavior. The primary goal is to determine whether the recruitment of an infralimbic (IL) cortex driver circuit is a hallmark of heroin-induced pathology, whether this IL subcircuit engages a positive feedback loop via the orexin system to perpetuate heroin...
The federal Project Grant award R16GM153699, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the behavioral and neural mechanisms by which environmental enrichment can reverse the effects of chronic heroin use in rats. Specifically, the $150,000 award, with a period of performance from September 10, 2024 to June 30, 2028, will: Characterize adaptations in dopamine...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $284,040 to The Lieber Institute for Brain Development to conduct research on the molecular and circuit-level changes in the habenula brain region associated with opioid exposure. The study aims to generate a spatially-resolved atlas of opioid-induced gene expression changes in the rodent habenula at the cellular and circuit level, and to...
This is a Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279). The $3,472,327 grant, awarded on May 15, 2024, will support a 5-year research project entitled "The Impact of Poly-Substance Use on the Crosstalk between Microglia, Astrocytes, and Neurons that Regulates HIV Latency." The project, led by Case Western Reserve University, aims to investigate how the combined use of methamphetamine and opioids...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,411,610 in funding to the University of Nebraska Medical Center (UNMC) to investigate the combined effects of HIV Tat protein and opioids on glial-neuronal interactions, with a focus on the role of extracellular microRNAs. The research aims to elucidate how HIV and opioid co-morbidity exacerbates synaptic injury and dysfunction, and to...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $149,284 to the University of Washington to investigate the role of prefrontal cortex pyramidal neuron subpopulations in regulating drug-seeking behavior. The research will use fiber photometry and chemogenetic techniques to characterize alterations to intratelencephalic (IT) and pyramidal tract (PT) neuron activity in the prelimbic region of the...
This $751,043 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research investigating the cellular and molecular mechanisms underlying the complex co-occurrence of opioid use disorder (OUD), major depressive disorder (MDD), and HIV in the human brain. The award will fund a comprehensive study using advanced multi-omics approaches, including single-nucleus RNA sequencing and single-nucleus ATAC...