This Project Grant award of $159,615 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to predict craving and relapse in opioid use disorder using neurobehavioral markers of goals and habits. The key objectives are to: Track daily changes in motivational control during inpatient heroin addiction treatment with and without fentanyl use, to understand how goal-directed control evolves with abstinence. Use the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,876 to conduct preclinical trials targeting the neuropeptide S (NPS) receptor to mitigate opioid taking and seeking behaviors in animal models. The goals of the project are to demonstrate proof-of-concept that NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation in rats, which could inform the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $903,965 to the University of Alabama at Birmingham (UAB) to conduct research on prefrontal cortex circuits that control heroin seeking behavior. The goal is to determine if the recruitment of a specific prefrontal cortex circuit that drives heroin seeking is a hallmark of opioid use disorder (OUD) pathology, whether this circuit engages a...
This $2,419,326 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study to investigate neurobehavioral and psychosocial predictors of health risk behaviors (HRBs) in adolescence and young adulthood. The primary awardee, Virginia Polytechnic Institute & State University, will conduct assessments over 15 years to understand brain development and its impact on substance use and...
This Project Grant award of $415,250, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to elucidate the role of cortical astroglia in heroin seeking behaviors. The award will fund a 2-year project at the Medical University of South Carolina (MUSC) to investigate how astroglial activity patterns evolve during heroin self-administration and subsequent heroin seeking, and how modulating astroglial...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the "Behavioral and Neurobiological Mechanisms of Reciprocal Social Interactions in Substance Use Disorders." The $641,450 award to the University of Maryland, Baltimore aims to study how drug use, particularly heroin, leads to social isolation as partners fail to reciprocate social interactions. The research will...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,073,250 to the University of California, San Diego (UCSD) to investigate age-related differences in opioid reward and addiction. The funded studies will use rat models to determine how the middle-adult developmental stage may influence sensitivity to prescription opioids, heroin, and fentanyl, compared to younger adulthood. The research aims...
This $284,040 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to conduct integrated single-cell and spatial mapping of the habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure. The Lieber Institute for Brain Development in Baltimore, MD will lead this research effort from September 1, 2024 to August 31, 2026. The project will generate a...