This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to uncover the neural circuit mechanisms that generate dopamine neuron activity and dopamine reward prediction error (RPE) signals. The $656,073 award to President and Fellows of Harvard College will support three key research objectives: Examining the roles of glutamate and GABA inputs to dopamine neurons in generating dopamine RPE...
This $284,040 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to conduct integrated single-cell and spatial mapping of the habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure. The Lieber Institute for Brain Development in Baltimore, MD will lead this research effort from September 1, 2024 to August 31, 2026. The project will generate a...
This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research into the neural circuitry underlying goal-directed and habit learning behaviors. The $162,672 award, with a performance period from August 1, 2024 to March 31, 2028, will be used by the University of California, Los Angeles (UCLA) to conduct an in-depth investigation of the role of dopaminergic projections to the...
The National Institute on Drug Abuse (NIDA) awarded a $1,039,420 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Medical University of South Carolina (MUSC). The grant, effective June 1, 2025 through February 28, 2030, will support research to characterize the transcriptomic profile and function of single neurons and unique neuronal ensembles in brain circuits that govern the facilitation and disinhibition of alcohol and opioid seeking behaviors. The project...
The University of Washington was awarded a $149,284 Project Grant by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of specific subpopulations of prefrontal cortex pyramidal neurons in regulating drug-seeking behavior. The research aims to elucidate the factors that predispose individuals to addiction and confer vulnerability to relapse, with the goal of advancing understanding of the functional roles of...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the NIH's Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $751,043 research project at the University of Massachusetts Medical School focused on investigating the cellular and molecular mechanisms underlying the complex co-morbidity of opioid use disorder (OUD), major depressive disorder (MDD), and HIV in the human brain. The project will leverage single-cell sequencing technologies and other...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate corticolimbic circuit and neuroimmune mechanisms underlying HIV-induced dysregulation of reward-seeking behavior. The research aims to use optogenetic and chemogenetic techniques to stimulate the infralimbic cortex-nucleus accumbens shell circuit and modulate microglial function to rescue HIV-induced...
This $1,351,034 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the mechanisms by which somatostatin-expressing interneurons in the prefrontal cortex of the brain regulate natural and drug reward seeking behaviors. The key objectives are to: 1) reveal the in vivo dynamics, behavioral contributions, and neural circuit connections of these interneurons during natural and...
This Cooperative Agreement award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $2,154,700 to President and Fellows of Harvard College to develop a "Virtual Rat" simulation platform for studying sensorimotor control and brain organization. The key products being developed include highly realistic neural network-based computational models of rat behavior and biomechanics, which will enable advanced...
This $254,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to characterize a specialized serotonergic-septohippocampal brain circuit and its role in modulating context-triggered drug-seeking behavior and relapse vulnerability. The research will be conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, from July 2024 through June 2026. Specifically, the grant will support foundational studies to delineate the intrinsic properties of a specific subtype of serotonergic neurons (R2HOXA2-PET1) and their interaction with a novel cell type (LSI-R2P neurons) in the lateral septum, which may underlie the propensity for context-triggered drug-seeking behavior and relapse. This work may have substantial translational value by revealing circuits, cells, and signaling pathways that influence the vulnerability for relapse in substance use disorders.