This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This $254,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to characterize a specialized serotonergic-septohippocampal brain circuit and its role in modulating context-triggered drug-seeking behavior and relapse vulnerability. The research will be conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, from July 2024 through June 2026. Specifically, the grant...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research at Duke University to elucidate the function of the ventral tegmental area (VTA) circuits and their contribution to the learning and performance of motivated behaviors. The $629,844 award, with a project period from May 1, 2025 to February 28, 2030, will leverage bidirectional optogenetics, in vivo electrophysiology, photometry, and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 - Drug Use and Addiction Research Programs, provides $162,672 in funding to the University of California, Los Angeles (UCLA) to conduct a study on the role of dopamine projections to the amygdala in goal-directed and habit learning. The research aims to use in vivo fiber photometry imaging and optogenetic manipulation techniques to characterize the function of the ventral tegmental area...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $818,513.00 to investigate the role of dopamine signaling in the basolateral amygdala on individual differences in reward-learning strategies and addiction-like behaviors. The 5-year study, starting on September 15, 2024, will focus on how Pavlovian reward-learning strategies, such as sign tracking versus goal tracking, predict unique...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $529,878 to support research aimed at understanding the molecular mechanisms underlying dopamine desensitization and its relationship to motivational disruptions associated with mental illnesses such as depression, addiction, and bipolar disorder. The principal investigator will...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate corticolimbic circuit and neuroimmune mechanisms underlying HIV-induced dysregulation of reward-seeking behavior. The research aims to use optogenetic and chemogenetic techniques to stimulate the infralimbic cortex-nucleus accumbens shell circuit and modulate microglial function to rescue HIV-induced...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research at Vanderbilt University to investigate the circuit mechanisms underlying inflexible habitual behaviors following chronic cocaine use. The $136,929 award, effective from April 1, 2025 to March 31, 2027, supports experiments to: 1) determine how a history of cocaine self-administration alters dopamine release to promote habitual...
The University of California, Los Angeles (UCLA) was awarded a $613,017 Project Grant under the National Institutes of Health's (NIH) Drug Use and Addiction Research Programs (CFDA 93.279) to support research on the neural circuit mechanisms underlying the timing of dopamine reward omission signals and their role in reinforcement learning. The project, which runs from July 1, 2025 to March 31, 2030, aims to advance the understanding of how dopamine and striatal dynamics interact to encode...