Project Grant R21AG104791
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded University of California, San Diego $165,488 on March 1, 2026, under the Aging Research program (CFDA 93.866) to reduce misdiagnosis in Alzheimer's disease through artificial intelligence-driven biomarker identification. The project constructs a comprehensive multidimensional database by repurposing over 1,500 limited-volume dementia samples using Silver-Seq, a small input liquid volume extracellular RNA sequencing technique, spanning 25 years of diverse...
- The National Institute on Aging awarded $654,506 to The Regents of The University of Colorado, doing business as University of Colorado-Denver, on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into glial-associated immune dysregulation in Alzheimer's disease pathology, specifically investigating how reactive astrocytes drive immune dysfunction, alter dendritic structure in the brain, and contribute to synaptic dysfunction and cognitive decline. The...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The Regents of The University of Colorado on July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity and subsequently disrupts sleep architecture in Alzheimer's disease. The research examines whether beta-amyloid accelerates death of hypocretin neurons...
- The National Institute on Aging awarded Colorado State University $808,980 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop quantile-focused statistical tools and multimodal analyses that identify nonlinear genetic variants and interactions shaping Alzheimer's disease risk and cellular pathogenesis across key brain cell states. The project will create a comprehensive, distribution-aware genetic architecture atlas and deliver four primary products: quantile-specific...
- The National Institute on Aging, under the Department of Health and Human Services, awarded Duke University $627,830 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a portable diagnostic system for Alzheimer's disease detection using circulating microRNA biomarkers. Duke's project, titled ADMIRE (Alzheimer's Detection via miRNA Evaluation), integrates two technologies: an amplification-free microRNA biosensing modality called the Inverse Molecular Sentinel and a...
- The National Institute on Aging awarded The Regents of The University of Colorado, doing business as University of Colorado-Denver, $669,195 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate financial toxicity and cognitive impairment in Medicare Advantage enrollees with Alzheimer's disease and related dementias. The research team will leverage and expand a unique data linkage of Medicare claims and consumer credit records to examine financial burden in Medicare...
- The National Institute on Aging awarded The Regents Of The University Of Colorado (doing business as University Of Colorado-Denver) $783,984 on March 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a multisite randomized controlled trial of GAPcareAD, a brief emergency department intervention addressing fall-related care needs for persons living with dementia and their care partners. The intervention adapts the GAPCARE fall prevention program for patients with Alzheimer's...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded The Johns Hopkins University $680,637 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a pragmatic clinical trial improving cognitive impairment screening in older adults with diabetes. The funded work develops and validates novel tools using natural language processing and large language models to identify cognitive impairment and Alzheimer's disease and related dementias screening events in electronic health records. The...
The National Institute on Aging awarded the University of Colorado-Denver $429,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop clinical decision support tools and implementation guidance for primary care clinicians and patients navigating Alzheimer's disease blood biomarker testing and diagnostic decision-making. The project, R21AG104791, addresses a gap in primary care capacity to diagnose Alzheimer's disease and incorporate newly FDA-approved blood biomarkers into cognitive impairment workups. Primary care clinicians report low comfort with AD etiology diagnosis and limited confidence in emerging diagnostic methods, yet most mild cognitive impairment and dementia cases are diagnosed in primary care rather than subspecialty settings. The award funds development of a patient-centered decision support tool and implementation guide co-designed with patients, family members, and clinicians using the Ottawa Decision Support Framework. In Aim 1, the research team will conduct a decision needs assessment and interview approximately 40 participants total (patients, family, and clinicians) to inform rigorous multi-step tool refinement. Performance runs from September 1, 2026, through August 31, 2028, at the University of Colorado-Denver campus in Aurora, Colorado. This is a Project Grant, a type of assistance award under the National Institute on Aging's biomedical and behavioral research portfolio focused on aging, Alzheimer's disease prevention and treatment, and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 8/24/26 |