Project Grant R01AG102573
- The National Institute on Aging awarded $654,506 to The Regents of The University of Colorado, doing business as University of Colorado-Denver, on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into glial-associated immune dysregulation in Alzheimer's disease pathology, specifically investigating how reactive astrocytes drive immune dysfunction, alter dendritic structure in the brain, and contribute to synaptic dysfunction and cognitive decline. The...
- The National Institute on Aging awarded $442,485 to The Regents of the University of Colorado (doing business as University of Colorado-Denver) on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate selective vulnerability of the locus coeruleus and hypothalamus to herpes simplex virus type 1 infection in Alzheimer's disease progression. The research employs spatial transcriptomics and proteomics via the NanoString GeoMx DSP platform alongside in vivo electrophysiological...
- The National Institute on Aging awarded The Washington University $642,991 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate genetic drivers of phenotypic variability in autosomal dominant Alzheimer's disease using a multi-omics approach. The research identifies genetic alterations associated with Alzheimer's disease risk and presentation in individuals carrying mutations in the PSEN1, APP, and PSEN2 genes. The project characterizes transcriptomic brain profiles...
- The National Institute on Aging awarded the University of Colorado-Denver $429,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop clinical decision support tools and implementation guidance for primary care clinicians and patients navigating Alzheimer's disease blood biomarker testing and diagnostic decision-making. The project, R21AG104791, addresses a gap in primary care capacity to diagnose Alzheimer's disease and incorporate newly FDA-approved blood...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Regents of the University of Colorado (University of Colorado-Denver) $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and test novel nasal formulations of granulocyte-macrophage colony-stimulating factor (GM-CSF) for treating Alzheimer's disease and related neurodegenerative disorders. The research addresses limitations of subcutaneous GM-CSF administration...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The Regents of The University of Colorado on July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity and subsequently disrupts sleep architecture in Alzheimer's disease. The research examines whether beta-amyloid accelerates death of hypocretin neurons...
- The National Institute on Aging awarded Arizona State University $431,750 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the mechanisms underlying the protective effects of the RELN-COLBOS variant in Alzheimer's disease. The funded research leverages stem cell bioengineering, genome editing, and neurodegenerative disease modeling to elucidate the neuroprotective mechanisms of the RELN-COLBOS variant, a rare Reelin variant identified in a PSEN1 mutation carrier...
- The National Institute on Aging, an office of the National Institutes of Health, awarded the University of California, Davis $683,331 under the Aging Research program (CFDA 93.866) on September 1, 2026, to identify and validate causal risk genes and proteins contributing to Alzheimer's disease and its neuropsychiatric symptoms. The research integrates genome-wide association study (GWAS) findings with functional omics data from post-mortem brain tissues to pinpoint proteins mediating Alzheimer's...
- The National Institute on Aging awarded the University of Pittsburgh $619,577 on September 1, 2026, under the Aging Research program (CFDA 93.866) for statistical methods development in spatial proteogenomics data analysis applied to Alzheimer's disease research. The project develops computational and statistical methods to advance spatial proteogenomics analysis, which integrates spatially resolved protein and transcript information to examine cellular organization in brain tissue. In Aim 1,...
- The National Institute on Aging awarded The Leland Stanford Junior University $125,766 on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify molecular mediators linking cardiometabolic risk factors to Alzheimer's disease. The research identifies plasma protein and metabolite mediators of cardiometabolic pathways that contribute to Alzheimer's disease risk using large-scale omics data from the UK Biobank and Million Veteran Program. The project comprises three specific aims:...
The National Institute on Aging awarded Colorado State University $808,980 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop quantile-focused statistical tools and multimodal analyses that identify nonlinear genetic variants and interactions shaping Alzheimer's disease risk and cellular pathogenesis across key brain cell states. The project will create a comprehensive, distribution-aware genetic architecture atlas and deliver four primary products: quantile-specific Bayesian fine-mapping (QSUSIE) to localize variants whose effects peak in distribution tails and test quantile-specific dominance and epistasis; quantile-aware colocalization (QCOLOC) and quantile transcriptome-wide association study (QTWAS) framework to integrate single-nucleus RNA-seq, chromatin accessibility, and proteomic data across cell types; an Alzheimer's-focused sequence model (EVO2-AD) that generates nonlinear, cell-contextual variant scores using parameter-efficient adapters; and an openly disseminated toolkit with MIT-licensed R/Python packages, containers, digital object identifiers, and a public API. The work is performed at Colorado State University's Sponsored Programs division in Fort Collins, Colorado, with a period of performance extending through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $127.3k | 8/20/26 | ||
| Not listed | $681.7k | 8/19/26 |