Project Grant R01AG101783
- The National Institute on Aging awarded $442,485 to The Regents of the University of Colorado (doing business as University of Colorado-Denver) on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate selective vulnerability of the locus coeruleus and hypothalamus to herpes simplex virus type 1 infection in Alzheimer's disease progression. The research employs spatial transcriptomics and proteomics via the NanoString GeoMx DSP platform alongside in vivo electrophysiological...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The Regents of The University of Colorado on July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity and subsequently disrupts sleep architecture in Alzheimer's disease. The research examines whether beta-amyloid accelerates death of hypocretin neurons...
- The National Institute on Aging awarded The Regents Of The University Of Colorado, doing business as University Of Colorado-Denver, $1,390,204 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the interaction between systemic endothelial glycocalyx fragility and brain dysfunction in aged sepsis survivors. The project will investigate pathologic organ crosstalk between the systemic vasculature and brain following sepsis, with particular focus on...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Regents of the University of Colorado (University of Colorado-Denver) $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and test novel nasal formulations of granulocyte-macrophage colony-stimulating factor (GM-CSF) for treating Alzheimer's disease and related neurodegenerative disorders. The research addresses limitations of subcutaneous GM-CSF administration...
- The National Institute on Aging awarded The Regents of The University of Colorado, doing business as University of Colorado-Denver, $669,195 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate financial toxicity and cognitive impairment in Medicare Advantage enrollees with Alzheimer's disease and related dementias. The research team will leverage and expand a unique data linkage of Medicare claims and consumer credit records to examine financial burden in Medicare...
- The National Institute on Aging awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $189,963 on July 1, 2026, under the Aging Research program (CFDA 93.866) to support research led by Dr. Carlisle investigating the contributions of biological sex and sex hormones to cognitive reserve across the cognitive spectrum of Alzheimer's disease. The research will assess how estrogen and sex differences affect Alzheimer's disease risk, with particular...
- The National Institute on Aging awarded the University of Colorado-Denver $429,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop clinical decision support tools and implementation guidance for primary care clinicians and patients navigating Alzheimer's disease blood biomarker testing and diagnostic decision-making. The project, R21AG104791, addresses a gap in primary care capacity to diagnose Alzheimer's disease and incorporate newly FDA-approved blood...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded Colorado State University $808,980 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop quantile-focused statistical tools and multimodal analyses that identify nonlinear genetic variants and interactions shaping Alzheimer's disease risk and cellular pathogenesis across key brain cell states. The project will create a comprehensive, distribution-aware genetic architecture atlas and deliver four primary products: quantile-specific...
- The National Institute on Aging awarded The Regents Of The University Of Colorado (doing business as University Of Colorado-Denver) $783,984 on March 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a multisite randomized controlled trial of GAPcareAD, a brief emergency department intervention addressing fall-related care needs for persons living with dementia and their care partners. The intervention adapts the GAPCARE fall prevention program for patients with Alzheimer's...
The National Institute on Aging awarded $654,506 to The Regents of The University of Colorado, doing business as University of Colorado-Denver, on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into glial-associated immune dysregulation in Alzheimer's disease pathology, specifically investigating how reactive astrocytes drive immune dysfunction, alter dendritic structure in the brain, and contribute to synaptic dysfunction and cognitive decline. The research addresses temporal biological pathways and neuroanatomical mechanisms underlying the relationships between astrocyte reactivity, immune dysregulation, Alzheimer's disease pathology, and cognitive decline in aging adults. Two primary aims guide the work: delineating astrocyte-related molecular alterations in the blood immune milieu longitudinally while assessing whether age and amyloid pathology differentially impact these networks, and evaluating whether astrocyte-related blood immune networks herald changes in neuritic brain structure. The research also examines whether astrocyte reactivity catalyzes downstream blood immune dysfunction to identify more accessible immune biomarkers for tracking Alzheimer's disease pathological cascades. Performance occurs in Aurora, Colorado. The period of performance runs from September 1, 2026, through May 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $654.5k | 8/18/26 |