Project Grant R00AG086609
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $578,856 under the Aging Research program (CFDA 93.866) on February 15, 2026, to support research on sleep's role in mitigating neurodegenerative disease. The primary deliverable is a comprehensive research program investigating how sleep reinforces homeostatic set-points in neural activity, particularly criticality—an optimal computational regime that maximizes...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $249,797 to Washington University's Office of Sponsored Research Services on September 15, 2025, under the Aging Research program (CFDA 93.866). The award supports research examining the epigenetic mechanisms through which sleep loss contributes to neurodegeneration in tauopathies, particularly Alzheimer's disease. The research deliverables include investigation into how sleep deprivation and...
- Federal Grant Award Summary The University of California, San Diego received a $182,173 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded March 1, 2026, with a completion date of February 28, 2031. This grant funds research focused on understanding how the locus coeruleus—a neuromodulatory center in the brain—orchestrates sleep-dependent memory consolidation processes. The research deliverables include the development of computational...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $1.48 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded March 15, 2026, with completion scheduled for February 28, 2031. The grant supports research investigating "The Proteomic Signature of Sleep and Its Implication for Alzheimer's Disease," addressing the established relationship between sleep disruption and cognitive decline in...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Colorado-Denver a Project Grant of $442,485 under the Aging Research program (CFDA 93.866) for the period June 1, 2026, through May 31, 2028. The research project investigates selective vulnerability of the locus coeruleus and paraventricular nucleus of the hypothalamus to Herpes Simplex Virus Type 1 (HSV-1) infection in Alzheimer's disease (AD) progression. The primary deliverables include research...
- Federal Grant Award Summary Washington State University received a $420,750 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 5, 2025, with completion targeted for July 31, 2027. The grant supports research investigating reciprocal interactions between cognitive performance, beta-amyloid (AB) aggregation, transcriptional processing, and sleep disruption in an Alzheimer's disease model. The project addresses a critical gap in understanding how...
- Grant Award Summary The National Institute on Aging (NIA) awarded University of California, Irvine a $1.24 million Project Grant under the Aging Research program (CFDA 93.866) to conduct a five-year longitudinal study examining the relationships between Alzheimer's disease (AD) pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The award, effective February 1, 2026 through January 31, 2031, funds research designed to address a critical gap in...
- Federal Grant Award Summary The National Institute on Aging awarded a K23 (Mentored Patient-Oriented Research Career Development) grant of $145,706 to the University of Miami's Office of Research Administration—School of Medicine on July 1, 2026, under the Aging Research program (CFDA 93.866). This award supports both research and structured career development training for a clinical sleep neurologist through April 30, 2031. The grant delivers a comprehensive training framework consisting of...
- Federal Grant Award Summary Florida State University's Sponsored Research Administration Division received a $296,232 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective March 15, 2026, with a completion date of February 29, 2028. The award funds basic neuroscience research investigating how thalamic spike dynamics regulate sleep stability and memory consolidation in normal and diseased brain conditions. Using optogenetics,...
- Federal Grant Award Summary The University of Michigan received a $107,097 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded September 16, 2025, with a completion date of June 30, 2027. This research project investigates the relationship between sleep disturbances and age-related memory impairment, with the objective of understanding how disrupted sleep alters hippocampal neuron function and connectivity in aging populations. The research will...
The University of Colorado received a $249,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded July 1, 2026, with a completion date of March 31, 2029. This award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity in the lateral hypothalamus, leading to sleep disturbances characteristic of Alzheimer's disease. The research deliverables include experimental demonstrations of altered hypocretin neuron excitability in Alzheimer's disease models, mechanistic studies of how beta-amyloid drives neuronal hyperexcitability and neuronal loss, and analysis of the relationship between disrupted homeostatic sleep pressure and fragmented sleep architecture observed in Alzheimer's patients. The research integrates neuroscience and gerontology approaches to clarify the biological pathways linking amyloid pathology to sleep dysfunction in aging and neurodegeneration. By establishing hypocretin neurons as a central integration hub mediating the interaction between amyloid accumulation and sleep disruption, this work contributes to the NIA's mission of understanding aging processes and identifying prevention and treatment strategies for Alzheimer's disease and related dementias. The project is performed at the University of Colorado's location in Palo Alto, California.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 7/3/26 |