Project Grant R01AG100293
- Federal Grant Award Summary Duke University's Office of Research Administration received a $426,555 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2027. The award supports the development and technical evaluation of CASCADE AMPLIFICATION BY RECYCLING TRIGGER PROBE (CARTP), a novel molecular diagnostic technology designed to enable rapid, multiplex, and ultra-sensitive detection of circulating...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Duke University $493,972 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cell type-specific epitranscriptomic regulation in the brain during aging and Alzheimer's disease. The research will determine how age-dependent differential methylation of adenosine (M6A) in distinct brain cell types influences the expression of genes associated with Alzheimer's disease. The...
- The National Institute on Aging awarded University of California, San Diego $165,488 on March 1, 2026, under the Aging Research program (CFDA 93.866) to reduce misdiagnosis in Alzheimer's disease through artificial intelligence-driven biomarker identification. The project constructs a comprehensive multidimensional database by repurposing over 1,500 limited-volume dementia samples using Silver-Seq, a small input liquid volume extracellular RNA sequencing technique, spanning 25 years of diverse...
- The National Institute on Aging awarded Exqor Technologies Inc. $999,176 on September 22, 2025, under the Aging Research program (CFDA 93.866) to develop non-radioactive nanoprobes for magnetic resonance imaging of tropomyosin receptor kinase B (TrkB) in Alzheimer's disease. The project addresses early detection of decreased TrkB expression, which is implicated in impaired neurogenesis, synaptic damage, and neuronal death in Alzheimer's disease. The recipient is developing a two-part...
- The National Institute on Aging awarded $526,607 to Wake Forest University on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational imaging frameworks that integrate neuroimaging with multi-omics data to identify Alzheimer's disease subtypes and model neurodegenerative progression with calibrated uncertainty. The project, titled "Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease," will...
- Federal Project Grant Award Summary Meganano Diagnostics Inc. received a $483,346 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 15, 2025, with a completion date of August 31, 2026. The grant funds the development of an reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay designed to enable early diagnosis of Alzheimer's disease (AD) using accessible peripheral blood biomarkers. The project...
- The National Institute on Aging awarded the University of California, San Diego $150,512 on August 2, 2026, under the Aging Research program (CFDA 93.866) to develop and validate a novel diffusion MRI neuroimaging biomarker for early detection of Alzheimer's disease. The project focuses on microstructural changes in gray matter mean diffusivity (GMD) that may precede macrostructural atrophy visible on conventional MRI. Current AD detection relies primarily on macrostructural metrics such as...
- The National Institute on Aging, part of the National Institutes of Health, awarded $1,250,191 to the University of North Carolina at Chapel Hill on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence and experimental workflow for accelerating discovery of small-molecule modulators that influence Alzheimer's disease through microglial phagocytosis regulation. The funded work combines AI-driven computational methods with...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to investigate the presence of Alzheimer's disease (AD) biomarkers in nasally exhaled breath. The $440,000 award to Northwestern University will fund research to test the hypothesis that neural proteins associated with AD, such as tau and beta-amyloid, can be detected and quantified in nasally exhaled breath samples. The 2-year project period runs from...
The National Institute on Aging, under the Department of Health and Human Services, awarded Duke University $627,830 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a portable diagnostic system for Alzheimer's disease detection using circulating microRNA biomarkers. Duke's project, titled ADMIRE (Alzheimer's Detection via miRNA Evaluation), integrates two technologies: an amplification-free microRNA biosensing modality called the Inverse Molecular Sentinel and a plasmonic super-bright bimetallic nanostar chip platform for surface-enhanced Raman scattering detection. The system aims to enable rapid, non-invasive, sample-to-answer diagnosis of Alzheimer's disease from patient plasma without the need for RT-PCR. The research includes designing and validating IMS probes for microRNA biomarkers identified through next-generation sequencing analysis of plasma from early Alzheimer's patients and healthy age-matched controls. Analytical validation will compare results from the ADMIRE system against traditional RT-PCR methods. The work is performed in Durham, North Carolina, with a period of performance from September 1, 2026, to May 31, 2031. This is a Project Grant award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $627.8k | 8/18/26 |