Project Grant R21AG103782
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $154,960 to the University of Kansas Medical Center Research Institute, Inc. on February 26, 2026, under the Aging Research program (CFDA 93.866). The recipient will conduct research combining cellular and clinical measures to examine bioenergetic contributions to tau phosphorylation in aging and Alzheimer's disease. The work leverages existing clinical data from the KU...
- Federal Project Grant Award Summary The National Institute on Aging awarded Oklahoma Medical Research Foundation (OMRF) a $2.6 million Project Grant under the Aging Research program (CFDA 93.866) to conduct biomedical research on mitochondrial dysfunction in Alzheimer's disease. Awarded September 15, 2025, and extending through August 31, 2029, this grant funds research investigating how mitochondrial adenosine monophosphate-activated protein kinase (AMPK) signaling governs mitochondrial...
- Federal Grant Award Summary The University of Oklahoma Health Sciences Center received a $286,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 15, 2025, through August 31, 2027. This novel pilot study investigates microvascular endothelial lipid metabolism as a therapeutic target for age-related vascular cognitive impairment. The research will examine how dysregulated lipid homeostasis and lipid droplet (LD) accumulation in brain...
- The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to...
- The National Institute on Aging awarded the University of Utah $612,346 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate age-associated decline of meningeal gamma-delta T cells and their modulation by the gut-meninges axis. Research will examine fundamental mechanisms of how age influences meningeal gamma-delta T cells, their regulation by gut microbiota, and gut-centric interventions that drive their rebound in advanced age, with the goal of identifying...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $3,253,590 to the University of Kansas Medical Center Research Institute, Inc. on August 1, 2026, under the Aging Research program (CFDA 93.866) to conduct NEO-FLAME, an ancillary mechanistic study investigating how neuro-energetic and oxidative processes mediate the long-term effects of exercise on cognition and brain health in older adults. The award funds a...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded the University of California, San Diego $408,012 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop methods for improving central nervous system pharmacokinetics of targeted protein degraders through specialized assay workflows and prodrug chemistries. The research will establish dual-functional molecules that hijack endogenous molecular transport pathways to cross the blood-brain barrier, with early-stage application to...
The National Institute on Aging awarded the University of Oklahoma Health Sciences Center $214,500 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate alpha-ketoglutarate as a therapeutic intervention to improve neurogliovascular coupling and cognitive function in older adults. The project will evaluate whether dietary alpha-ketoglutarate supplementation can restore the impaired blood-flow-to-brain-activity coupling mechanism that declines with age, specifically by reducing oxidative stress within neurogliovascular unit cells and assessing effects on cognitive performance in human subjects. The award supports a two-year period of performance through August 31, 2028, with work performed in Oklahoma City, Oklahoma. This is a Project Grant, an assistance type designed to support biomedical, social, and behavioral research directed toward understanding aging processes and age-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $214.5k | 8/31/26 |