Project Grant RF1AG091787
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $154,960 to the University of Kansas Medical Center Research Institute, Inc. on February 26, 2026, under the Aging Research program (CFDA 93.866). The recipient will conduct research combining cellular and clinical measures to examine bioenergetic contributions to tau phosphorylation in aging and Alzheimer's disease. The work leverages existing clinical data from the KU...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $301,575 to the Palo Alto Veterans Institute for Research on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a two-year project grant testing the combined effectiveness of the anti-amyloid medication lecanemab and exercise training for Alzheimer's disease treatment. The recipient will use the 3XTG-AD mouse line to evaluate whether...
- The National Institute on Aging, a division of the Department of Health and Human Services, awarded $506,198 to Ceiba Bio Inc. on September 15, 2025, under the Aging Research program (CFDA 93.866) to develop platelet-derived exercise mimetics as a treatment for Alzheimer's disease and Alzheimer's disease-related dementias. The award funds a fast-track Phase I to Phase II project translating prior research identifying exercise-induced platelet-derived factors in blood plasma that mediate...
- The National Institute on Aging awarded the University of Oklahoma Health Sciences Center $214,500 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate alpha-ketoglutarate as a therapeutic intervention to improve neurogliovascular coupling and cognitive function in older adults. The project will evaluate whether dietary alpha-ketoglutarate supplementation can restore the impaired blood-flow-to-brain-activity coupling mechanism that declines with age, specifically...
- The National Institute on Aging awarded the University of Kansas Medical Center Research Institute, Inc. $3,254,395 on July 1, 2026, under the Aging Research program (CFDA 93.866) to implement and evaluate the Brain Health Care Accelerator (BHCA), a clinical and systems intervention designed to improve Alzheimer's disease and related dementias detection in primary care. The BHCA integrates structured cognitive assessments, blood biomarkers including plasma phosphorylated tau-217, electronic...
- The National Institute on Aging awarded the University of Kansas Medical Center Research Institute, Inc. $1,111,002 on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate mitochondria-nuclear communication via lactylation in Alzheimer's disease. The research addresses the hypothesis that mitochondrial dysfunction in Alzheimer's disease leads to increased glycolysis and elevated lactate production, which induces lactylation of histones and non-histone proteins....
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $3.23 million to the University of Kansas Center for Research Inc. under the Aging Research program (CFDA 93.866) to investigate the interplay between neuronal activity, synaptic dysfunction, and mitochondrial dysfunction in Alzheimer's disease. The project, initiated September 30, 2025, and running through August 31, 2029, will utilize mouse models of Alzheimer's disease to examine age-dependent and region-specific...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $3,253,590 to the University of Kansas Medical Center Research Institute, Inc. on August 1, 2026, under the Aging Research program (CFDA 93.866) to conduct NEO-FLAME, an ancillary mechanistic study investigating how neuro-energetic and oxidative processes mediate the long-term effects of exercise on cognition and brain health in older adults. The award funds a five-year follow-up assessment within the FLAME (Follow-Up Longitudinal Assessment of Moderate Exercise) study, which evaluates whether a one-year aerobic exercise intervention produces lasting cognitive and brain health benefits and alters trajectories of Alzheimer's disease neuropathology. NEO-FLAME employs an innovative neuro-energetic and oxidative imaging platform to elucidate mechanistic pathways. The study hypothesizes that neuro-energetic markers via NAD and ATP, combined with oxidative measures including oxygen extraction and cerebral antioxidant status indexed by brain glutathione, jointly mediate the sustained impact of exercise on cognition and brain health, leveraging comprehensive physiological, behavioral, metabolic, genetic, molecular, cognitive, and neuroimaging datasets. Work is performed at the recipient's Kansas City, Kansas facility. The period of performance runs from August 1, 2026, through July 31, 2030. This is a Project Grant, the assistance type for discrete research projects under the NIA's Aging Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 7/23/26 |