Project Grant R21AG101600
- Federal Project Grant Award Summary The National Institute on Aging awarded $433,125 to the University of Texas Health Science Center at San Antonio under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2027. This exploratory/developmental grant funds research investigating whether extracellular tau protein modulates neurogenesis through the low-density lipoprotein receptor related protein 1 (LRP1) in adult-born granule neurons. The project...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $3.18 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 13, 2025, with completion targeted for July 31, 2029. This award supports research investigating the spatial organization and conformational ensembles of alpha-synuclein (α-syn) amyloids within cellular environments. The project delivers scientific research products...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Illinois a $6.67 million Project Grant under the Aging Research program (CFDA 93.866) to develop small molecule ligands targeting pathological tau signaling in Alzheimer's disease and related dementias. The award, effective September 1, 2025, through August 31, 2029, supports the identification and optimization of small molecule inhibitors designed to block the tau phosphatase activating domain (PAD), a toxic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $681,908 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of November 30, 2030. This project grant supports biomedical research directed at understanding protective mechanisms in tauopathies, a class of neurodegenerative diseases characterized by pathological tau protein aggregation, including Alzheimer's...
- Federal Grant Award Summary New York University received a $422,297 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through January 31, 2028. This research project investigates the mechanisms by which frontotemporal dementia (FTD)-associated tau mutations dysregulate protein synthesis in human neurons. The primary deliverables include scientific research utilizing human induced pluripotent stem cell (iPSC)-derived...
- Federal Project Grant Award Summary The University of Illinois received a $1,592,854 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2027. This award funds research investigating tau protein conformation in tauopathies, including Alzheimer's disease and related dementias such as progressive supranuclear palsy, cortical basal degeneration, and chronic traumatic encephalopathy. The research centers on...
- Federal Project Grant Award Summary Ohio University received a $567,256 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with a completion date of January 31, 2029. This three-year research project investigates the mechanisms of activity-dependent tau protein release from neurons, with emphasis on understanding how neuronal hyperexcitability contributes to Alzheimer's disease (AD) pathogenesis. The research employs...
- Federal Grant Award Summary New York University School of Medicine received a $390,906 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 15, 2025, with a completion date of March 31, 2030. The award funds research investigating the selective vulnerability of basal forebrain cholinergic neurons (BFCNs) to tau pathology in Alzheimer's disease. The project delivers three integrated research components: (1) biochemical and...
- The University of Texas Southwestern Medical Center received a $456,500 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct a two-year research project (February 1, 2026 – January 31, 2028) investigating the role of heparan sulfate proteoglycans (HSPGs) in tau protein uptake within cell and mouse models. The research aims to identify the specific heparan sulfate size and sulfation code patterns required for tau binding in neurons and...
- Federal Project Grant Award Summary The University of Texas Medical Branch at Galveston received a $617,349 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded June 15, 2026, with a completion date of March 31, 2031. The award funds research investigating EPAC1 signaling as a novel mechanism of retinal neurodegeneration during tauopathy—a pathological condition characterized by abnormal tau protein aggregation associated with Alzheimer's...
The University of Texas Southwestern Medical Center received a $441,126 project grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period July 1, 2026 through June 30, 2028. The award funds research investigating the molecular mechanisms by which Stimulator of Interferon Genes (STING) regulates tau seeding and tauopathy in Alzheimer's disease (AD). The research addresses a critical gap in understanding how extracellular tau fibrils enter the cytoplasm and promote the pathological spreading of tau aggregates that correlates with cognitive decline. The project will deliver two primary research products through its defined aims: (1) elucidation of the molecular mechanism by which STING promotes tau seeding in cellular models, and (2) genetic determination of the role of distinct STING functions in mouse tauopathy models. This research tests an alternative hypothesis to the conventional understanding that the cGAS-STING innate immune signaling pathway contributes to AD neuroinflammation solely through immune mechanisms, instead proposing that STING-induced disruption of endolysosomal pH promotes tau endolysosomal escape and subsequent tau-related neurodegeneration. Completion of these research objectives will advance scientific understanding of tau propagation mechanisms relevant to AD pathogenesis and may inform future therapeutic intervention strategies.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.1k | 6/18/26 |