Project Grant RF1AG096441
- This $1,592,854 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Illinois to investigate the role of tau protein misfolding and hyperphosphorylation in Alzheimer's disease and related dementias. The central hypothesis is that pathogenic forms of tau represent a disruption of tau's normal scaffolding and signaling functions, leading to dysregulation of key kinases like CK2 and JNK. The research aims to define how...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Jillion Therapeutics Inc. aims to identify small molecule compounds that can bind to and modify the biological behavior of tau protein, which is implicated in Alzheimer's disease and other neurodegenerative "tauopathies". The $496,373 award, spanning September 2024 to August 2025, will utilize the company's DNA-encoded library (DEL) drug discovery platform to screen a large chemical...
- This federal Project Grant award of $437,250.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development of new imaging tools to study the various forms of the tau protein, which is implicated in Alzheimer's disease. The goal is to create a peptide-based probe that can detect tau in its soluble, liquid-liquid phase separation, and liquid-solid phase separation states within living cells using an aggregation-induced emission (AIE) approach. This...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $307,312 Project Grant to the University of Iowa to investigate the reversal of tau protein pathology in serotonergic neurons as a potential therapeutic intervention for early-stage Alzheimer's disease and related dementias (ADRD). This 7-month project aims to determine if restoring the function of the PP2A phosphatase enzyme can reduce abnormal tau phosphorylation and mitigate the...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $165,348.00 to the Rector & Visitors of the University of Virginia to investigate the cellular and molecular mechanisms by which hyperphosphorylated tau protein induces neurotoxicity and cognitive deficits. The research aims to characterize the effects of hyperphosphorylated tau oligomers on brain function using transcriptomic profiling and neurophysiology approaches. Specifically, the...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This Project Grant award of $1,257,528 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Novoron Bioscience Inc. is focused on developing a platform to evaluate novel therapies designed to inhibit the propagation and aggregation of pathological tau protein, which is a key driver of Alzheimer's disease and other tauopathies. The platform will leverage human induced pluripotent stem cell (hiPSC)-derived neural organoids, including both wild-type and LRP1 knockout organoids, to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $757,027 to the University of Washington to conduct research on the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease. The research aims to identify mechanisms that drive the interaction between these two pathological hallmarks of Alzheimer's and how they contribute to cognitive decline and neurodegeneration. Key activities include using C. elegans models to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,336,256.00 to the University of Illinois to develop small molecule ligands that target pathological tau signaling in Alzheimer's disease and related dementias. The research aims to identify candidate molecules that can block the toxic effects of misfolded tau protein, which is a key driver of neurodegeneration in these diseases. The grant will fund the screening and initial optimization of these small molecule "tau phosphatase activating domain (PAD) ligands" that have demonstrated the ability to prevent axonal degeneration and cell death in cell-based models of tau pathology. The award period runs from September 1, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 8/26/25 |