Project Grant R15AG098725
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $2.35 million Project Grant to The Regents of the University of California, San Francisco, under the Aging Research program (CFDA 93.866) to conduct comprehensive research on aberrant proteomes in tauopathy. The award, which commenced June 1, 2025, and extends through February 28, 2030, funds an interdisciplinary research initiative combining mass spectrometry-based proteomics and functional genomics expertise to...
- Summary of Federal Project Grant Award The Ohio State University received a $657,000 project grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This research initiative, titled "Uncovering the Role of WFS1 Deficiency in Selective Vulnerability in Alzheimer's Disease," will investigate the molecular mechanisms underlying selective neuronal vulnerability to tau protein aggregation...
- Grant Award Summary The University of Illinois received a $1,592,854 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 1, 2025, with a completion date of May 31, 2027. This award supports scientific research investigating tau protein conformation and dysfunction in tauopathies, including Alzheimer's disease and related dementias such as progressive supranuclear palsy, cortical basal degeneration, and chronic traumatic...
- Federal Project Grant Award Summary Case Western Reserve University's Office of Research Administration received a $161,000 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 15, 2025, with a completion date of May 31, 2027. The award funds scientific research investigating the regulatory mechanisms of tau protein metabolism in Pick's disease, a neurodegenerative tauopathy characterized by abnormal tau accumulation. The research...
- Federal Project Grant Award Summary Case Western Reserve University received a $442,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective May 15, 2025, with a completion date of April 30, 2027. The research focuses on developing synthetic replicas of tau-dependent protein 43 (TDP-43) filaments associated with frontotemporal dementia and related neurodegenerative diseases. The primary deliverables include an experimental model...
- Federal Project Grant Award Summary The National Institute on Aging awarded $433,125 to The University of Texas Health Science Center at San Antonio on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct exploratory research investigating the relationship between extracellular tau protein and neurogenesis through the Low-Density Lipoprotein Receptor Related Protein 1 (LRP1). The project, with a completion date of August 31, 2027, focuses on understanding how tau...
- Federal Project Grant Award Summary Case Western Reserve University received a $431,750 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective January 1, 2026 through December 31, 2027, to conduct research investigating the role of CHCHD10 (coiled-coil-helix-coiled-coil-helix domain-containing protein 10) in tauopathy associated with Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathology (FTLD-TAU). The research will...
- Federal Project Grant Award Summary Northeastern University received a $2.24 million project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded May 15, 2025, with completion targeted for February 28, 2030. The award funds comprehensive proteogenomic profiling research to characterize aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The research integrates genomic, transcriptomic, and proteomic data through a...
- Federal Grant Award Summary The National Institute on Aging awarded University of California, Irvine a $773,816 Project Grant under the Aging Research program (CFDA 93.866) on June 1, 2025, with a completion date of March 31, 2030. This award funds a multi-investigator research initiative investigating cell-type-specific and spatial proteogenomics analysis of aberrant RNA splicing and misfolded proteins in Alzheimer's-related tauopathies. The research team will generate single-cell spatial...
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Florida $419,375 under the Aging Research program (CFDA 93.866) to investigate the pathological implications of tau protein and RNA interactions in neurodegenerative diseases, particularly Alzheimer's disease and related tauopathies. The 12-month project, which commenced on June 1, 2025, aims to identify and characterize specific RNA motifs that bind to tau protein across different disease progression...
Award Overview:
Ohio University received a $567,256 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2029. The award supports scientific research investigating the mechanisms of activity-dependent tau release in Alzheimer's disease (AD) pathogenesis, with the goal of elucidating how neuronal hyperexcitability contributes to tau propagation between neurons. Research Deliverables:
The project delivers three primary research aims. Aim 1 investigates the mechanism of activity-dependent tau release from neurons and synapses using a Drosophila model, focusing on how synaptic vesicle proteins regulate human tau release. Aim 2 employs an unbiased proteomic screening approach to identify and characterize novel tau-interacting proteins involved in activity-dependent tau release beyond pre-selected candidates. Aim 3 validates and extends findings from the first two aims. The research utilizes both Drosophila neuromuscular junction models and human neural cell lines to advance understanding of tau release mechanisms linked to early Alzheimer's disease pathogenesis, with findings potentially informing therapeutic interventions targeting tau propagation and neurodegeneration.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $567.3k | 1/21/26 |