Project Grant RF1NS143938
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will provide $2,280,379 to the Regents of the University of Michigan to develop novel nanobody-based agents that can target pathogenic alpha-synuclein to block its cell-to-cell transmission. The grant aims to characterize these nanobody-based agents and assess their in vitro and in...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable...
- This three-year, $3.4 million Project Grant from the National Institute on Aging will support research into the combinatorial effects of post-translational modifications on alpha-synuclein structure, function, and aggregation. The Trustees of the University of Pennsylvania will investigate how multiple simultaneous modifications to alpha-synuclein impact its interactions with lipid bilayers, self-association kinetics, aggregate structural features, internalization by neurons, and seeded...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- The National Institute on Aging (NIA) awarded a $717,491 Project Grant under its Aging Research program (CFDA 93.866) to New York University (NYU) School of Medicine to develop single domain antibodies (sdAbs) that can detect and clear alpha-synuclein (αSyn) in animal models of synucleinopathies. The project aims to evaluate the in vivo imaging potential, clearance mechanisms, and therapeutic efficacy of these sdAbs targeting αSyn, a key protein involved in neurodegenerative diseases like Lewy...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $506,000 Project Grant to the Scripps Research Institute to engineer a novel biomolecular condensate (BMC)-based tool with tunable physicochemical properties. The goal is to create an orthogonal selective autophagy receptor (SAR)-like BMC capable of supporting autophagosome biogenesis and selective cargo recruitment. This will enable detailed investigation of the biophysical regulatory mechanisms of BMCs in autophagy, which...
- This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,178,675 to investigate the spatial organization and conformational ensembles of alpha-synuclein (a-syn) amyloids inside cells. The project aims to identify the prevalent a-syn amyloid conformations and their abundances in biological settings, which could enhance understanding of amyloid propagation and aid in identifying biologically relevant structures. Key objectives include comparing amyloid propagation in vitro versus inside biosensor cell lines and neurons, and analyzing amyloid structures from tissue-seeded Lewy body formations. The award was granted to the University of Texas Southwestern Medical Center, a prominent academic medical research institution, with a project period from August 13, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 8/12/25 |