Project Grant R21AG093455
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $472,073 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) beginning September 1, 2025, with completion targeted for May 31, 2030. Under the Aging Research program (CFDA 93.866), this award funds scientific research investigating the role of tau-induced changes in post-translational modifications—specifically sumoylation and succinylation—in mitochondrial-nuclear...
- Federal Project Grant Award Summary New York University School of Medicine received a $130,302.00 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded July 15, 2025, with a project completion date of March 31, 2030. The grant funds scientific research directed toward understanding the selective vulnerability of basal forebrain cholinergic neurons (BFCNs) to tau pathology in Alzheimer's disease. The research deliverables include...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a project grant of $119,367.00 to The Regents of the University of California, San Francisco under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award, made on August 11, 2025, with completion expected July 31, 2027, funds research investigating the RNA-related function and dysfunction of tau protein in frontotemporal...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $2.35 million Project Grant to The Regents of the University of California, San Francisco (UCSF) under the Aging Research program (CFDA 93.866) to investigate aberrant proteomes in tauopathy and their functional consequences through multimodal proteomics. The award, effective June 1, 2025, through February 28, 2030, funds a collaborative research initiative combining mass spectrometry-based proteomics and...
- Federal Grant Award Summary The University of Florida Division of Sponsored Research received a $419,375 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2026. The award supports research investigating the pathological implications of tau-ribonucleic acid (RNA) interactions in tauopathies, particularly Alzheimer's disease (AD). The project aims to identify and characterize RNA motifs that bind...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $681,908 to the University of California, San Francisco (UCSF) under the Aging Research program (CFDA 93.866), with an award date of February 15, 2026, and completion date of November 30, 2030. This research initiative, titled "Mechanisms of Protective UFM1-Dependent IRE1 Signaling in Tauopathies," will deliver scientific research and development services directed toward understanding...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a $1,526,066 Project Grant effective June 1, 2025, through April 30, 2030, under the Aging Research program (CFDA 93.866). This research initiative investigates shared mechanisms of tau toxicity across neurodegenerative diseases, with particular focus on understanding the mechanistic connection between tau abnormality and mitochondrial dysfunction. The project aims to elucidate how tau...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $805,573 under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of June 30, 2030. This Project Grant supports comprehensive biomedical research investigating the impact of N6-methyladenosine (M6A) RNA modifications in Alzheimer's disease and related tauopathies. The research deliverables include identification of specific RNA...
- Federal Project Grant Award Summary The National Institute on Aging awarded Ohio University a $567,256 Project Grant effective February 1, 2026 through January 31, 2029 under the Aging Research program (CFDA 93.866). This award supports scientific research investigating the mechanisms of activity-dependent tau protein release and propagation in Alzheimer's disease pathogenesis. The research deliverables include three primary research objectives: (1) investigating the mechanism of...
- Federal Project Grant Award Summary Boston University Medical Campus received a $1.70 million project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with a completion date of May 31, 2030. This award funds biomedical research investigating transfer RNA (tRNA) modifications and their role in translational dysfunction in Alzheimer's disease and related disorders (ADRD). The research examines how dysregulation of tRNA...
Project Grant Award: Mechanisms of Dysregulated Translation in Human Neurons Carrying FTD-Associated Tau Mutations New York University received a $422,297 project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 15, 2026, with completion scheduled for January 31, 2028. This award funds fundamental research investigating how frontotemporal dementia (FTD)-associated mutations in the tau protein disrupt protein synthesis mechanisms in human neurons. The research employs human induced pluripotent stem cell (iPSC)-derived neurons as an experimental model to identify how pathogenic tau mutations impact translation elongation rates, ribosome efficiency, and tau-ribosome interactions using ribosome profiling and related molecular techniques. The primary deliverables include scientific findings characterizing the translatome and translational efficiency changes associated with FTD-related tau mutations, mechanistic insights into how tau mutations alter tau-ribosome interactions and cause ribosome collisions, and publications advancing understanding of tau-related pathobiology in tauopathies including Alzheimer's disease and frontotemporal dementia. These research products contribute to the National Institute on Aging's mission of supporting biomedical research directed toward understanding age-related neurodegenerative diseases and identifying potential intervention targets for diseases affecting older adults.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.3k | 2/5/26 |