Project Grant R21AG101515
- Federal Grant Award Summary Mayo Clinic received a $3.38 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded September 15, 2025, with completion targeted for September 14, 2029. The grant supports research to advance women-specific care in Alzheimer's disease and other dementias through systematic analysis of electronic health records (EHRs). The project addresses a critical gap in precision medicine by examining women-specific health...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital (MGH) a Project Grant totaling $2,315,831 (awarded September 1, 2025; completion date May 31, 2030) under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the relationship between menopause-related vasomotor symptoms and cardiovascular disease (CVD) risk in midlife women. The research addresses a significant clinical gap: while hot flashes...
- Federal Grant Award Summary The University of Delaware received a $1.3 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of February 1, 2026, and a completion date of January 31, 2031. This five-year research initiative investigates the sympathetic nervous system (SNS) changes occurring during the menopausal transition and their contribution to elevated cardiovascular disease mortality in perimenopausal women....
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center (BIDMC) received a $1.69 million Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), with an award date of September 15, 2025, and completion date of May 31, 2029. This research project investigates the role of orexin neuropeptides in the severity of menopausal symptoms using a mouse model, addressing a significant public health need...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Missouri System a Project Grant in the amount of $433,125 under the Aging Research program (CFDA 93.866) to support a two-year research initiative running from June 1, 2026, through May 31, 2028. The funded research addresses beta-3 adrenergic receptor (β3-AR) signaling and its role in cardiovascular function among aging women, with the overarching objective of identifying personalized therapeutic...
- Federal Project Grant Award Summary Mayo Clinic received a $745,851 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2030. The award supports a five-year research initiative examining the integration of inspiratory muscle training (IMT) into cardiac rehabilitation (CR) protocols for patients with heart failure with reduced ejection fraction (HFrEF). The...
- Federal Grant Award Summary The National Institute on Aging awarded a Project Grant totaling $552,154 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Aging Research program (CFDA 93.866). The award, effective February 1, 2026, through November 30, 2030, supports research aimed at improving hormone therapy (HT) use in women experiencing premature or early menopause. The project will generate research products and findings addressing a critical...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $429,000 to the University of Colorado-Denver under the Aging Research program (CFDA 93.866) for a two-year project period spanning January 1, 2026, through December 31, 2027. The award funds biomedical research aimed at understanding the role of estradiol in regulating protein crotonylation—a post-translational modification—in aged female hearts. Specifically, the research will investigate how decreased estradiol levels...
- Federal Project Grant Award Summary Mayo Clinic received a $660,157 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026, through January 31, 2031. The grant supports basic biomedical research investigating the role of BRD4 (bromodomain-containing protein 4) in enhancing donor heart preservation quality, with particular focus on expanding the utilization of older donor hearts for transplantation. The research addresses a...
- Federal Grant Award Summary Mayo Clinic Arizona received a $160,092 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with an award date of December 21, 2025, and completion date of July 1, 2027. The grant funds a multisite, longitudinal research study designed to characterize sleep health, sleep disorders, and cognitive functioning in adult heart transplant recipients. This investigation addresses a...
Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $439,258 to Mayo Clinic, with an award date of June 15, 2026, and completion date of May 31, 2028, under the Aging Research program (CFDA 93.866). The project, titled "Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women," will investigate the efficacy of high-resistance inspiratory muscle strength training in reducing sympathetic nerve activity and improving sleep quality in postmenopausal women experiencing vasomotor symptoms (hot flashes). The research addresses the significant health burden of hot flashes, which affect over 70% of menopausal women and have been associated with increased risk of hypertension, cardiovascular disease, and sleep and mood disorders. The project comprises two primary research aims: (1) determining whether six weeks of high-resistance inspiratory muscle strength training reduces sympathetic nerve activity in postmenopausal females with hot flashes, and (2) establishing whether the same intervention improves sleep through reductions in nocturnal awakenings by decreasing hot flash frequency. The research will be conducted at Mayo Clinic's Rochester, Minnesota location and will generate objective measures of neurovascular function to provide evidence-based, non-pharmacological intervention options for managing menopause-associated symptoms and reducing cardiovascular disease risk in midlife women.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $439.3k | 6/16/26 |