Project Grant R01HL176491
- This $886,411 Project Grant was awarded on January 1, 2025 by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the Mayo Clinic in Minnesota. The grant supports a Translational Training in Respiratory Disease and Repair program, which aims to train the next generation of basic, translational, and clinician scientists to advance respiratory medicine and fully restore respiratory function. The program will provide mentorship and research opportunities...
- This federal Project Grant award for $569,695.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research into the therapeutic potential of phrenic proprioceptors, or sensory neurons, to restore respiratory function after cervical spinal cord injury. The research, conducted by Marquette University, aims to test the hypothesis that activating these phrenic proprioceptors can induce spinal plasticity and improve breathing...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the oxygen cost of breathing and its impact on dyspnea and exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). The award aims to understand how obesity-related mechanical ventilatory constraints...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $477,290 to Mayo Clinic to investigate the underlying behavioral mechanisms that impact a home-based pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). The research aims to determine the associations between patterns of physical activity, sedentary behavior, sleep, and cognitive...
- The National Institutes of Health, through the Medical Library Assistance (CFDA 93.879) federal grant program, awarded a $390,852 Project Grant to the Mayo Clinic in Minnesota to conduct a multicenter randomized clinical trial on virtual world-based cardiac rehabilitation. The study aims to promote data-powered cardiovascular health and improve outcomes for cardiac patients, despite the well-established benefits of reduced mortality and improved quality of life from cardiac rehabilitation. The...
- This federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the use of NNMT inhibition to treat heart failure. The $736,089 grant supports research to determine if increased NNMT activity, leading to NAD+ deficiency, is central to the pathophysiology of both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). The...
- The University of Florida received a $149,348 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the cellular mechanisms of acute-intermittent hypercapnic-hypoxia induced phrenic motor plasticity. The project will monitor phrenic nerve activity in anesthetized rats as a proxy for respiratory motor output, with the goal of enhancing understanding of the pathways involved in phrenic long-term facilitation (PLTF)...
- The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $774,997 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the contribution of medullary pre-sympathetic neurons to the progression of breathing disorders and autonomic dysfunction in heart failure with preserved ejection fraction (HFPEF). The project aims to provide in-vivo and in-vitro neuronal activity mapping of the...
- This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a study to investigate the impact of selective vagal neuromodulation on heart failure indices. The 2-year project, with a start date of September 1, 2025, will be conducted by the University of Colorado-Denver. The research aims to better understand the neural interface by studying the effects of selective activation of cholinergic (efferent)...
- This federal Project Grant award of $333,810 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop the RMT Complete, an all-in-one respiratory muscle training device and mobile application. The RMT Complete is designed to enhance breathing function and quality of life for patients with chronic obstructive pulmonary disease (COPD) by combining features such as an integrated manometer, wide resistance training...
The federal Project Grant award, titled "Adding Inspiratory Muscle Training to Optimize Cardiac Rehabilitation for Heart Failure," is funded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research). The $745,851 grant, awarded on September 1, 2025, supports research aimed at improving exercise tolerance and reducing exertional symptoms in patients with heart failure with reduced ejection fraction (HFrEF). The key objectives are to: 1) test if inspiratory muscle training (IMT) combined with cardiac rehabilitation (CR) improves locomotor muscle blood flow during exercise compared to CR alone, and 2) assess if IMT combined with CR reduces the exaggerated inspiratory muscle oxygen cost of breathing and improves ventilatory function. The grant recipient is Mayo Clinic, a renowned non-profit academic medical center in Minnesota specializing in medical research, clinical practice, and education.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $745.9k | 8/20/25 |