Project Grant R01HL180648
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $1,127,798 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). This 7-year grant, effective February 1, 2025, will support research to understand the role of macrophages in preserving cardiovascular health, illuminating their contributions to cardiovascular disease, and...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) is providing $628,753 to SRI International to conduct research on the thermoregulatory physiology of menopausal hot flashes. The goal is to determine if precisely timed and targeted localized peripheral cooling can mitigate menopausal hot flashes. The research will combine a novel hot flash detection algorithm developed by SRI with a novel cooling approach to help alleviate this...
- This federal Project Grant award of $198,549.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to determine the contribution of HIV and menopausal phase to cardiovascular disease (CVD) risk parameters and subclinical atherosclerosis in women with HIV. The study aims to (1) assess the association of HIV and menopausal phase with CVD risk factors, (2) evaluate the relationship between HIV, menopausal phase, immune...
- The National Heart, Lung, and Blood Institute (NHLBI), through the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $162,384 Project Grant to Dr. Ester Oh at the University of Colorado-Denver. The grant will fund research to evaluate the efficacy and mechanisms of equol supplementation for improving vascular function in postmenopausal women with chronic kidney disease (CKD). The research aims to advance understanding of sex-specific cardiovascular disease risk factors and...
- This Project Grant award of $432,250.00 was issued on September 15, 2025 by the Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award was provided to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts to conduct research on the role of orexin neuropeptides in regulating sleep disturbances, anxiety, and hot flashes experienced by women during the menopausal transition. The project aims to...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,559,542 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Medical College of Wisconsin, Inc. (MCW) to study the cardiometabolic impact of gender-affirming hormone therapy (GAHT) in transgender and gender diverse (TGD) young adults. The study aims to better define the vascular and cardiometabolic effects of modern GAHT in this population, as current knowledge relies on limited data. The 14-month...
- The federal Project Grant award titled "CARDIAC EFFECTS OF MINERALOCORTICOID RECEPTOR ANTAGONISM AFTER PREECLAMPSIA (CARDAMOM)" was awarded by the National Heart, Lung, and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital, for $658,418.00. The award aims to conduct a randomized, double-blind clinical study investigating whether mineralocorticoid receptor blockade can promote favorable...
- This Project Grant award, valued at $167,400.00 and awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), will support research by Brigham & Women's Hospital Inc. to investigate how the immune mediator CD70 regulates endothelial metabolism and function, with the goal of identifying novel therapeutic targets for atherosclerotic cardiovascular disease. The 5-year project will comprehensively examine the role of CD70 in impairing endothelial...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $170,640 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), on August 15, 2025. The grant supports research by Dr. Tristan Kooistra, a physician-scientist at MGH and Harvard Medical School, to investigate how epithelial-derived Notch signals promote the maturation of airway macrophages and influence allergic...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $834,531 to The General Hospital Corporation, doing business as Massachusetts General Hospital, to conduct research on the effects of IL-1 beta inhibition on vascular inflammation in individuals with clonal hematopoiesis of indeterminate potential (CHIP), a risk factor for atherosclerotic cardiovascular disease. The research aims to investigate vascular...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $788,301 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant supports a 5-year research project to study the relationship between menopause-related vasomotor symptoms (hot flashes) and cardiovascular disease (CVD) risk among peri- and post-menopausal women with cardiometabolic risk factors. The project aims to examine the effects of hot flash burden on endothelial and coronary vascular function, and assess the impact of hot flash suppression using a novel neurokinin-3 receptor antagonist therapy on endothelial function and inflammation. The findings may provide mechanistic insights into how menopause-related symptoms contribute to heightened CVD risk in midlife women.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $788.3k | 9/1/25 |