Project Grant R21AG101519
- Federal Project Grant Award Summary The University of Missouri System received a $429,394 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded December 15, 2025, with completion targeted for November 30, 2027. This research initiative investigates LARP6 (LA Ribonucleoprotein 6) as a therapeutic target for treating heart failure with preserved ejection fraction (HFpEF) in aging populations with comorbid conditions such as obesity and...
- Federal Project Grant Award Summary The University of Missouri System received a $676,608 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026, with a completion date of December 31, 2030. This research project investigates the role of the gut-brain axis in Alzheimer's Disease (AD) mitigation through a translational study combining human clinical research and preclinical animal experiments. The project employs advanced neuroimaging...
- Federal Grant Award Summary The University of Missouri System received a $685,654 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) for research titled "Tissue Transglutaminase as a Therapeutic Target for Arterial Stiffening and Hypertension in Obesity." The award, effective September 1, 2025, through May 31, 2029, funds a comprehensive research initiative investigating the mechanisms by which...
- Federal Grant Award Summary The University of Delaware received a $1.303 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2031. This five-year award supports biomedical research investigating the sympathetic nervous system's role in cardiovascular disease risk during the menopausal transition in women. The research examines physiological changes in cardiovascular function as...
- Federal Grant Award Summary The University of Missouri System received a $418,822 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 5, 2026, through February 28, 2031. This award supports fundamental biomedical research focused on advancing mechanistic understanding of membrane interfaces, specifically addressing two critical research areas: (1) elucidating the mechanism...
- Federal Project Grant Award Summary The University of Missouri System received a $413,118 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through June 30, 2030. This five-year award supports fundamental research investigating organelle transport and organization mechanisms in mammalian oogenesis, with specific focus on how primary oocytes are determined during...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Maryland, Baltimore a $589,154 Project Grant (CFDA 93.866 – Aging Research) effective February 1, 2026, through January 31, 2031. The award funds development and validation of a normalized cerebrovascular reactivity (nCVR) magnetic resonance imaging technique designed to improve detection and assessment of vascular contributions to cognitive impairment in small-vessel disease (SVD) patients. The...
- Federal Grant Award Summary The University of Missouri System received a $429,797 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 24, 2026, through January 31, 2031. This award supports structure-function studies of apolipoprotein B100 (APOB), a critical protein involved in lipoprotein metabolism and lipid transport between the gastrointestinal tract, liver, and other tissues....
- Federal Grant Award Summary The University of Missouri System received a $769,792 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025 through April 30, 2030. This Maximizing Investigators' Research Award supports the Ulery Laboratory's research on peptide therapeutic delivery through biomodulatory materials design. The project aims to engineer biomaterials with...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Marquette University a Project Grant of $309,000 on May 15, 2026, under the Aging Research program (CFDA 93.866) to support a two-year research initiative concluding April 30, 2028. This project delivers longitudinal neuroimaging research and biomarker identification services focused on understanding how ovarian hormone loss interacts with Alzheimer's disease pathology to accelerate cognitive decline in women during...
The University of Missouri System received a $433,125 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) effective June 1, 2026 through May 31, 2028. This research initiative investigates beta-3 adrenergic receptor (β3-AR) signaling as a therapeutic mechanism to preserve vascular function and reduce cardiovascular disease risk in aging women. The project delivers comprehensive experimental research services examining whether acute β3-AR agonism, specifically using the FDA-approved compound vibegron, can attenuate sympathetic-mediated vasoconstriction and enhance endothelial function in postmenopausal women. The research addresses a critical gap in understanding sex-specific vascular protection mechanisms that decline following menopause, with the potential to inform personalized treatment approaches for cardiovascular disease prevention in aging populations. The award funds three primary research aims executed at the Columbia, Missouri facility: (1) determining acute β3-AR agonism effects on sympathetic vasoconstriction through cold pressor testing and vascular transduction assessment; (2) evaluating β3-AR agonism effects on endothelial function using flow-mediated dilation measurements; and (3) characterizing vascular endothelial β3-AR expression in aging women through analysis of venous endothelial cell samples. These research services advance the National Institute on Aging's mission to support biomedical research directed toward understanding aging processes and age-related diseases, with emphasis on identifying preventive and therapeutic interventions for age-related cardiovascular dysfunction in women.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 5/25/26 |