Project Grant R21AG098466
- Federal Grant Award Summary The University of California, San Diego received a $140,589 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on March 17, 2026, with a completion date of February 28, 2027. This award supports research investigating the molecular mechanisms by which ketogenic metabolites ameliorate Alzheimer's disease (AD) pathology. The project focuses on dissecting how beta-hydroxybutyrate (BHB), the primary ketone body...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Pennington Biomedical Research Center (PBRC) a $749,481 Project Grant under the Aging Research program (CFDA 93.866) beginning January 1, 2026, and concluding December 31, 2030. This research initiative will deliver a 12-week randomized controlled feeding trial examining the effects of low energy density dietary intervention combined with exercise on metabolic and musculoskeletal outcomes in older adults with obesity and...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $599,623 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026 through January 31, 2031. The award funds research investigating the synergistic effects of unacylated ghrelin (UNAG) combined with endurance exercise (EE) on sarcopenia—the age-related progressive loss of muscle mass and function—and mobility loss in older adults. The research aims to...
- Federal Grant Award Summary The University of Cincinnati's Sponsored Research Services Division received a $324,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 15, 2026, with completion targeted for January 31, 2028. This award funds comparative effectiveness and safety research evaluating glucagon-like peptide-1 (GLP-1) agonists as a preventive intervention for Alzheimer's disease progression in patients with mild cognitive...
- Federal Grant Award Summary Auburn University received a $166,152 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective March 1, 2026, through February 28, 2029, to investigate the role of microRNA-1 (miR-1) in regulating pyruvate metabolism and skeletal muscle metabolic dysfunction in patients with peripheral artery disease (PAD). The research aims to define the miR-1-regulated transcriptome and identify how miR-1 and its target genes contribute to...
- Project Grant Award Summary The University of Wisconsin-Madison received a $1,198,259 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 1, 2025 through May 31, 2030. This award supports research investigating the physiological and molecular mechanisms underlying calorie restriction (CR), prolonged fasting, and mTORC1 protein kinase function in aging and age-related diseases. The research employs controlled feeding regimens...
- Federal Project Grant Award Summary Panorama Research Incorporated received a $354,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on September 20, 2025, with an ultimate completion date of September 19, 2026. The grant funds the development of a novel therapeutic approach to address sarcopenia—the age-related loss of skeletal muscle mass, quality, and strength—which affects a significant portion of the elderly population, particularly those...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Wisconsin–Madison a Project Grant totaling $698,690 under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms underlying age-related skeletal muscle dysfunction. The five-year research initiative, commencing February 1, 2026 and concluding January 31, 2031, will deliver scientific research products focused on understanding how aging differentially affects slow versus fast...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $3.23 million to the University of Kansas Center for Research Inc. under the Aging Research program (CFDA 93.866) to investigate the interplay between neuronal activity, synaptic dysfunction, and mitochondrial dysfunction in Alzheimer's disease. The project, initiated September 30, 2025, and running through August 31, 2029, will utilize mouse models of Alzheimer's disease to examine age-dependent and region-specific...
- Federal Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) received a $1.11 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for May 31, 2030. The grant funds research investigating mitochondrial-nuclear communication mechanisms in Alzheimer's disease (AD), specifically examining how mitochondrial dysfunction leads to elevated lactate...
The National Institute on Aging (NIA) awarded the University of Alabama at Birmingham a $409,750 Project Grant on June 15, 2026, under the Aging Research program (CFDA 93.866) to conduct the KARMA-P (Ketogenic Approach to Restore Muscle in Older Patients with Community-Acquired Pneumonia) Trial. This double-blind, randomized pilot clinical trial will evaluate the safety, feasibility, and preliminary efficacy of a 10-day oral ketogenic diet intervention in 30 hospitalized older adults (age >65) with bacterial community-acquired pneumonia, comparing outcomes between ketogenic feeding (n=15) and standard hospital feeding (n=15) cohorts. The research addresses the clinical challenge of acute illness-induced muscle wasting in older hospitalized patients, which currently contributes to prolonged recovery and long-term physical decline despite conventional interventions. The study will generate comprehensive clinical and biological data through multiple assessment modalities conducted at baseline, post-intervention, hospital discharge, and one-month follow-up, including muscle mass measurement via ultrasound, inflammatory and metabolic biomarkers, gut microbiome composition analysis, physical function assessment, handgrip strength measurement, and activity level monitoring via accelerometry. Daily blood ketone level measurements will guide dietary adjustments to maintain ketosis during the intervention period. Findings from this pilot research will provide preliminary evidence regarding the efficacy of ketogenic feeding as a therapeutic approach to mitigate muscle loss and metabolic dysfunction in older patients with acute bacterial pneumonia, with completion anticipated by May 31, 2028.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $409.8k | 6/16/26 |