Project Grant R03AG098738
- Federal Grant Award Summary The National Institute on Aging awarded the University of California, Irvine a $3.22 million Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This research initiative examines the role of the retrosplenial cortex (RSC) in Alzheimer's disease (AD) pathogenesis through translational investigation combining mouse models and human studies. The primary deliverables include scientific findings...
- Federal Project Grant Award Summary Case Western Reserve University received a $1,256,627 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through January 31, 2031. The ADAPTT (Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets) initiative will deliver comprehensive genetic analysis services and research outputs aimed at identifying functional genes and genetic variations underlying...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant of $802,034 (obligated June 1, 2025) to develop a Multimodal, Multiscale and Multistage Systems Biology (M3SB) infrastructure supporting precision medicine research for Alzheimer's Disease and Alzheimer's Disease-Related Dementia (AD/ADRD). The project, funded under the Aging Research program (CFDA 93.866) with a...
- Federal Grant Award Summary S-3 Research LLC received a $999,556 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 20, 2025, with a completion date of September 19, 2026. The company is developing a multi-modal digital tool designed to improve diversity and inclusivity in Alzheimer's Disease and Related Dementias (ADRD) clinical trial participation. The deliverable consists of an integrated platform incorporating mobile...
- Federal Project Grant Award Summary The University of California, San Diego received a $3.14 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 15, 2025, with completion targeted for August 31, 2029. This award supports comprehensive research to elucidate human brain neuropeptidome signatures and their biosynthetic proteases in normal and Alzheimer's disease (AD) conditions. The research will utilize a multi-omics...
- Federal Project Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. received a $589,614 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 1, 2026, through December 31, 2030. The COMTAD (Cognitive Monitoring During Treatment for Alzheimer Disease) study will develop and validate a cognitive safety monitoring system designed to detect adverse side effects of anti-amyloid therapies used to...
- Federal Grant Award Summary The University of South Florida received a $3.3 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025 through August 31, 2029. This award supports the development of novel peptidomimetic biomaterials designed to inhibit amyloid-beta (Aβ42) aggregation as a therapeutic intervention for Alzheimer's disease. The primary deliverables include the rational design and synthesis of structurally...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $127,224 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support scientific investigation into the pathological mechanisms of Alzheimer's disease (AD). The project, which extends through August 31, 2028, will elucidate the role of s-nitrosylated phospholipase D3 (SNO-PLD3) in microglial and neuronal pathophysiology associated with AD. Specifically,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of California, Berkeley a $1,079,604 Project Grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research on heterogeneous causal pathophysiology in Alzheimer's disease (AD). The primary deliverables include the development of novel statistical methodologies for causal discovery that will identify population-specific pathophysiological pathways underlying AD progression....
- Federal Grant Award Summary The University of Toledo was awarded $387,549 through the National Institute on Aging's Aging Research program (CFDA 93.866) effective September 30, 2025, with a completion date of August 31, 2027. The project focuses on synthesizing and investigating L-rhamnose (L-RHA) and L-RHA-containing molecules to advance understanding of their therapeutic potential for Alzheimer's disease (AD). The research team will design and synthesize L-RHA derivatives with specific...
The University of Cincinnati's Sponsored Research Services Division received a $324,000 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 15, 2026, through January 31, 2028. This award funds a comparative effectiveness research study utilizing real-world data to evaluate glucagon-like peptide-1 (GLP-1) agonists as a preventive treatment for Alzheimer's disease progression in patients with mild cognitive impairment (MCI). The research deliverables include: (1) effectiveness analysis comparing GLP-1 agonist outcomes to non-users and anti-amyloid monoclonal antibody users; (2) safety assessment of GLP-1 agonists in MCI patients; and (3) cost-effectiveness evaluation using a target trial emulation framework applied to TriNetX real-world data. The project generates high-quality comparative evidence to inform clinical decision-making and guide future therapeutic trials by integrating real-world effectiveness, safety, and economic evaluation data. This research addresses a critical gap in treatment options for MCI patients, where FDA-approved interventions are currently limited despite the urgent need for preventive strategies prior to Alzheimer's disease onset. The findings will contribute to the National Institute on Aging's mission of supporting biomedical research directed toward understanding and treating age-related diseases, particularly Alzheimer's disease and related dementias.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $324.0k | 2/5/26 |