Project Grant R21AG095865
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- This federal Project Grant award of $152,237.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant supports research to investigate neuromuscular adaptation to exercise in the early stages of Alzheimer's disease (AD). The project aims to determine the neuromuscular adaptive response to endurance exercise training in AD mouse models before the onset of overt AD-like pathology. Key objectives include assessing mitochondrial...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- This $715,500 federal Project Grant awarded by the National Science Foundation's (NSF) Engineering program will support research at the University of Illinois to investigate the relationship between exercise and cognitive health. The project aims to determine how muscle contraction during exercise may influence the activity and growth of cells in the hippocampus, the part of the brain involved in memory and learning. The research will conduct in vitro experiments culturing mouse muscle and...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $1,000,000 in funding to Tufts University to study how a factor secreted from muscle regulates levels of neurotransmitter receptors in neurons that control movement in the roundworm Caenorhabditis elegans. The research aims to advance scientific understanding of how muscle releases factors that signal to the brain to control communication between neurons, which may provide...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $665,118 supports a study to examine the neural mechanisms underlying the benefits of aerobic exercise for advanced Parkinson's disease (PD) patients with deep brain stimulation (DBS) implants. The research will enroll 51 advanced PD patients with DBS to assess the impacts of voluntary and forced aerobic exercise on motor, cognitive, and dual-task performance. Neural activity...
- This Project Grant award of $673,012 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to understand the neuromechanical bases for the increased energy cost of walking in aging. The University of Massachusetts is the primary awardee, with the goal of determining how age-related changes in gait strategy combine with muscle weaknesses to increase the energy cost of walking in older adults. The research will address key knowledge gaps regarding relative...
- This $530,469 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rowan University aims to investigate the role of the protein orosomucoid1 in mitigating age-related muscle loss and dysfunction (sarcopenia). The central hypothesis is that enhancing autophagy (a cellular process) through administering TAT-BECLIN1 and combining it with exercise will boost orosomucoid1 levels and improve muscle function in aged mice. The project seeks to determine if...
This $454,938 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the impact of exercise on the aging nervous system. The project, led by Rutgers, The State University, will leverage the C. elegans worm model to characterize how regular exercise protects the nervous system against age-related dysfunction, including neuronal hyperactivity similar to brain aging in mammals. The research aims to elucidate the molecular mechanisms, particularly the role of the SOD-4 protein, that mediate the long-term systemic benefits of exercise and enable its protective effects against neurodegenerative conditions like Alzheimer's disease. The project will utilize advanced multi-neuron imaging techniques to assess changes in nervous system activity and connectivity with aging, providing valuable insights to enhance exercise-based interventions for healthy brain aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $454.9k | 8/5/25 |