Project Grant R01AG092298
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $405,045.00 to the University of Florida to study the neural mechanisms underlying locomotor adaptation deficits and freezing of gait in Parkinson's disease (PD) patients. The project aims to understand how abnormal neural oscillations in the globus pallidus internus (GPI) disrupt the regulation of human walking in PD. The research will utilize a split-belt treadmill paradigm and record local...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $771,627 provides funding to The Washington University to develop and evaluate a metacognitive strategy intervention for addressing cognitive decline in individuals with Parkinson's disease (PD). The long-term goal of the research is to reduce disability, improve quality of life, and delay dementia onset among people with PD by enabling them to cope with cognitive decline and perform...
- This $454,938 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the impact of exercise on the aging nervous system. The project, led by Rutgers, The State University, will leverage the C. elegans worm model to characterize how regular exercise protects the nervous system against age-related dysfunction, including neuronal hyperactivity similar to brain aging in mammals. The research aims to elucidate the molecular...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- This $112,158 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in basal ganglia neural activity associated with depression in Parkinson's disease (PD) patients. The research aims to determine the specific brain regions and networks involved, as well as evaluate the effects of deep brain stimulation (DBS)...
- This $715,500 federal Project Grant awarded by the National Science Foundation's (NSF) Engineering program will support research at the University of Illinois to investigate the relationship between exercise and cognitive health. The project aims to determine how muscle contraction during exercise may influence the activity and growth of cells in the hippocampus, the part of the brain involved in memory and learning. The research will conduct in vitro experiments culturing mouse muscle and...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $469,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Michigan Technological University. The grant, titled "Dissecting Neural Circuit Mechanisms Underlying Pallidal Deep Brain Stimulation," will fund research to identify the neural elements and circuits necessary for the therapeutic effects of deep brain stimulation (DBS) of the globus...
- This $506,198 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop platelet-derived exercise mimetics as a potential treatment for Alzheimer's disease and related dementias. The key objectives are to: 1) Generate various clones of the platelet-derived exercise mimetic with improved safety and retained functionality, 2) Optimize the expression and purification of this platelet-derived factor, and 3) Demonstrate that the engineered...
- This federal Project Grant award of $152,237.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant supports research to investigate neuromuscular adaptation to exercise in the early stages of Alzheimer's disease (AD). The project aims to determine the neuromuscular adaptive response to endurance exercise training in AD mouse models before the onset of overt AD-like pathology. Key objectives include assessing mitochondrial...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $705,385 to Northeastern University to conduct a large-scale study investigating mediators and moderators of executive function training in older adults. The study aims to improve the rigor and reproducibility of research on cognitive plasticity in older adults, many of whom are at risk for Alzheimer's disease and related dementias. The study will collect data from 1,250 older adults aged 60+ to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $665,118 supports a study to examine the neural mechanisms underlying the benefits of aerobic exercise for advanced Parkinson's disease (PD) patients with deep brain stimulation (DBS) implants. The research will enroll 51 advanced PD patients with DBS to assess the impacts of voluntary and forced aerobic exercise on motor, cognitive, and dual-task performance. Neural activity will be measured from the subthalamic nucleus via the DBS system and the cerebral cortex via EEG to determine the underlying neural mechanisms associated with potential exercise-induced improvements. The project will be conducted by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University over a 5-year period from September 2025 to August 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $665.1k | 9/11/25 |