Project Grant R15AG095821
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $170,900.00 to Rowan University to conduct research aimed at optimizing autophagy to counteract aging-induced muscle deterioration in mice. The central hypothesis is that combining the autophagy agonist TAT-Beclin1 with endurance exercise may enhance the benefits of exercise in halting the progression of sarcopenia, or...
- This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- The National Institute on Aging (NIA) awarded a $354,000 Project Grant under the Aging Research program (CFDA 93.866) to Panorama Research Incorporated, a for-profit biotech company in Sunnyvale, CA. The grant supports research to develop a novel therapy for sarcopenia, characterized by age-related loss of skeletal muscle mass, quality, and strength. The proposed therapy is based on the adipokine Isthmin 1 (ISM1), which has been shown to promote protein synthesis and suppress degradation...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This $454,938 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the impact of exercise on the aging nervous system. The project, led by Rutgers, The State University, will leverage the C. elegans worm model to characterize how regular exercise protects the nervous system against age-related dysfunction, including neuronal hyperactivity similar to brain aging in mammals. The research aims to elucidate the molecular...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- This federal Project Grant award of $3,251,767.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University supports research to understand how indoles from commensal gut bacteria can promote mobility and healthspan in aging animals, including mice, fruit flies, and nematodes. The research aims to elucidate the mechanisms by which indoles, acting through the aryl hydrocarbon receptor, can limit sarcopenia and preserve muscle function and mitochondrial health...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
This $530,469 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rowan University aims to investigate the role of the protein orosomucoid1 in mitigating age-related muscle loss and dysfunction (sarcopenia). The central hypothesis is that enhancing autophagy (a cellular process) through administering TAT-BECLIN1 and combining it with exercise will boost orosomucoid1 levels and improve muscle function in aged mice. The project seeks to determine if orosomucoid1 is necessary for the functional benefits observed from this integrative therapy approach. The award runs from August 2025 through July 2028 and will involve a proteomic analysis of gastrocnemius muscle samples to elucidate the underlying molecular mechanisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $530.5k | 8/12/25 |