Project Grant R21AG094690
- Federal Project Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $304,474 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective July 1, 2025, through March 31, 2029. This award funds research investigating neuromuscular adaptation to exercise in Alzheimer's disease (AD), with the primary objective of determining whether impaired bioenergetics in skeletal muscle and peripheral nerves...
- Federal Project Grant Award Summary Virginia Polytechnic Institute & State University received a $322,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for a two-year period from February 1, 2026 through January 31, 2028. The award supports research investigating mitochondria and synapse crosstalk in Alzheimer's disease (AD) circuit vulnerability, with the research to be conducted at Virginia Tech's Roanoke, Virginia facility. The project...
- Federal Project Grant Award Summary The University of Virginia received a $522,167 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 1, 2025, with a completion date of May 31, 2030. This research project investigates the mechanisms of ribosomal DNA (rDNA) instability during aging, with a focus on understanding how DNA double-strand breaks and genomic instability contribute to cellular aging. The research examines the roles of FOB1 and its...
- Federal Grant Award Summary Georgia TECH Research Corp received a $6.45 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded August 15, 2025, with completion targeted for July 31, 2029. The award funds a multi-institutional research initiative led by Principal Investigator Sawicki to identify multi-scale mechanisms underlying age-related increases in the metabolic cost of walking. The research leverages a...
- Federal Grant Award Summary Virginia Commonwealth University received a $552,883 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective January 1, 2026, through November 30, 2030. This research grant supports a scientific investigation into the selective vulnerability of cholinergic neurons in Alzheimer's disease (AD), with particular focus on understanding how soluble oligomeric amyloid-beta 42 (oAβ42) interacts with α7β2-containing...
- Federal Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $112,256 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 22, 2026, with completion targeted for March 31, 2027. The research investigates the epigenetic basis of monocyte exhaustion memory following sepsis, addressing a critical public health challenge wherein...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $599,623 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026 through January 31, 2031. The award supports biomedical research investigating the synergistic effects of unacylated ghrelin (UNAG) and endurance exercise on sarcopenia and age-related mobility loss. The research project will generate scientific knowledge regarding mitochondrial...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded George Washington University a $450,250 Project Grant (CFDA 93.866 - Aging Research) effective August 15, 2025, through July 31, 2026, to investigate the impact of early life stress (ELS) on vascular aging and cardiovascular disease (CVD) risk. The research employs a preclinical mouse model to elucidate mechanisms linking early life adversity to adult CVD susceptibility. The project delivers two primary research...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $668,290 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 15, 2026, with completion targeted for January 31, 2031. The award supports biomedical research directed toward understanding the role of docosahexaenoic acid (DHA), an omega-3 essential nutrient, in protecting against age-related diseases. The research addresses a critical gap in...
- Federal Project Grant Award Summary Oregon Health & Science University has been awarded $471,885 by the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct a two-year research project (Award Date: June 1, 2025; Completion Date: May 31, 2027) investigating the mechanisms by which hyaluronan protects brain vascular endothelial cells from ferroptosis. The research addresses vascular contributions to cognitive impairment and dementia (VCID), the second leading...
Virginia Polytechnic Institute & State University (Virginia Tech) received a $409,464 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded May 15, 2026, with completion scheduled for April 30, 2027. The research conducted at Virginia Tech's Blacksburg, Virginia facility focuses on understanding how obesity accelerates age-related memory decline through dysregulation of K63 polyubiquitination in the hippocampus. The project investigates the molecular mechanisms linking obesity and aging to cognitive impairment, building on preliminary findings that both conditions increase K63 polyubiquitination—a degradation-independent ubiquitin modification—in brain regions critical to memory formation. Addressing a significant public health challenge, given that approximately 33% of adults over age 70 experience age-related memory loss and nearly 40% of U.S. adults are obese, this research aims to determine whether obesity directly accelerates age-related memory decline through this specific molecular pathway. The deliverables include scientific research examining the interaction between obesity and aging in memory impairment and identifying potential therapeutic targets for intervention. The project specifically tests whether knockdown of K63 polyubiquitination in aged hippocampal tissue can reverse obesity- and age-related memory deficits, with potential implications for developing novel treatments for cognitive decline in aging populations. Research findings will contribute to the National Institute on Aging's mission to support biomedical and behavioral research directed toward understanding aging processes and developing prevention and treatment strategies for age-related conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $409.5k | 5/7/26 |