Project Grant R03AG093239
- Federal Project Grant Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $152,237 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective July 1, 2025, through March 31, 2029. This grant funds research investigating neuromuscular adaptation to exercise in Alzheimer's disease (AD), with the primary deliverable being scientific research findings on how exercise training affects skeletal muscle and...
- Federal Project Grant Award Summary Virginia Commonwealth University received a $552,883 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through November 30, 2030. The award funds research investigating the selective vulnerability of cholinergic neurons in Alzheimer's disease (AD), with emphasis on understanding how soluble oligomeric amyloid-beta 42 (oAβ42) interacts with α7β2-containing nicotinic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Kansas Center for Research Inc. a $3.23 million Project Grant under the Aging Research program (CFDA 93.866) to investigate the interconnected roles of neuronal activity, synaptic dysfunction, and mitochondrial dysfunction in Alzheimer's disease. The award, issued September 30, 2025, with completion scheduled for August 31, 2029, funds comprehensive biomedical research utilizing mouse models of...
- Federal Project Grant Award Summary The University of Texas at Austin received a $438,625 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion targeted for August 31, 2027. The research initiative, titled "Decoding the Heterogeneity of Interneuron Vulnerability in Aging and Alzheimer's Disease: An Ultraplex CLEM Approach," will deliver comprehensive scientific investigation into age-related...
- Federal Project Grant Award Summary Vanderbilt University received a $482.8K Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research) effective February 1, 2026, through January 31, 2031, to conduct research on sphingolipid-dependent remodeling of mitochondria in aging cells. The research project will deliver scientific findings and methodological advances addressing the mechanisms by which sphingolipid accumulation contributes to age-associated mitochondrial...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Broad Institute of MIT and Harvard a Project Grant of $610,836 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through May 31, 2030. This award supports research on genetic dissection of mitonuclear interactions in aging and neurodegenerative disease. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale...
- Grant Award Summary The Medical University of South Carolina received a $157,998 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective July 17, 2025, with a completion date of August 31, 2028. The award supports research investigating ceramide-induced mitophagy as a potential therapeutic strategy for Alzheimer's disease. The project focuses on understanding how ceramides, bioactive lipids that regulate mitochondrial quality control,...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $466,340 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion targeted for January 31, 2028. This award supports the development and pilot testing of nucleic acid nanoparticles (NANPs), a novel non-viral vector technology designed to deliver therapeutic nucleic acids—including short interfering RNAs (siRNAs), antisense...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of California, Irvine $2.49M under the Aging Research program (CFDA 93.866) to conduct scientific research investigating circuit vulnerability in the entorhinal cortex during tauopathy-related Alzheimer's Disease (AD). The project, which commenced September 15, 2025, and extends through August 31, 2029, focuses on identifying neuronal cell types in the lateral and medial entorhinal cortex that are...
Project Grant Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $322,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion scheduled for January 31, 2028. This R03 grant funds research investigating the crosstalk between mitochondrial dysfunction and synaptic vulnerability in Alzheimer's disease (AD), with particular focus on the entorhinal cortex-hippocampus circuit. The research utilizes acute brain slice preparations from control and AD model animals to examine how dysregulated mitochondrial calcium signaling contributes to circuit vulnerability and early memory impairment in AD. The deliverables from this two-year project include scientific research findings on the molecular mechanisms underlying AD pathology, specifically examining how excessive mitochondrial calcium uptake mediated by the mitochondrial calcium uniporter (MCU) drives synapse loss in vulnerable brain circuits. By identifying the crosstalk between dendritic mitochondria and synaptic function in the context of AD-related calcium dysregulation, this research aims to advance understanding of disease mechanisms and support identification of therapeutic targets for preventing or delaying AD progression. The National Institute on Aging prioritizes such biomedical research directed toward understanding aging processes and age-related diseases, with particular emphasis on Alzheimer's disease interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $322.0k | 1/21/26 |