Project Grant R21AG091052
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $245,434 project grant to Wake Forest University Health Sciences (WFUHS) to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The study aims to investigate how stress experienced across the lifespan, as well as perceived psychological stress, may impact cognitive decline and...
- This $880,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine the effects of daily stress, sleep, and sex hormones on accelerated vascular aging in premenopausal midlife women. The 2-year study, starting November 2024, will investigate how emotional reactivity to daily stressors and sleep variability contribute to vascular dysfunction prior to menopause, and how these factors interact with changes in estradiol levels. The...
- This Project Grant award of $3,304,237 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 40-year longitudinal study examining the links between early life adversity, cumulative life stress, and cellular aging in midlife women and their offspring. The study aims to assess which aspects of life course stress, including childhood, midlife, and cumulative stress, are associated with accelerated cellular aging at age 50. The study will repeat assessments of cell aging...
- This federal Project Grant award of $459,250.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is focused on investigating the impact of stress and resilience on the longitudinal trajectories of Alzheimer's disease (AD)-related brain pathology and cognitive function. The research aims to elucidate the mechanisms by which stress may predispose individuals to long-term cognitive changes and the development of AD. The awardee, The General Hospital...
- The National Institute on Aging (NIA) has awarded a $640,906 project grant under CFDA 93.866 Aging Research to the University of Wisconsin-Madison to conduct research on "Elucidating Cerebrovascular Disease Pathways to Cognitive Decline with Vascular Neuroimaging." The 5-year project aims to utilize advanced neuroimaging techniques to understand the vascular contributions to cognitive impairment and dementia (VCID), and assess their relationship to Alzheimer's disease proteinopathy....
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $699,344 to Albert Einstein College of Medicine to investigate the impact of surgical stress on age-related changes and resilience, with a focus on sex differences. The project aims to quantify the spatial, temporal, and sex-dependent effects of surgical stress on aging hallmarks and determine how resilience may modulate these relationships. The 2-year award period runs from September 1, 2025 to...
- The Washington University in St. Louis, Office of Sponsored Research Services Division, received a $2,133,060 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant will support research to investigate the sex-dependent effects of stress on the accumulation of amyloid-beta (Aβ) and tau proteins, which are hallmarks of Alzheimer's disease pathology. The study aims to elucidate the signaling pathways that mediate the differential...
- The National Institute on Aging (NIA) awarded a $785,348 project grant (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies in La Jolla, California. The project, titled "Chronic Sleep Disruption is a Stressor for Healthspan and Lifespan", will investigate the biological mechanisms by which chronic sleep disruption (CSD) may interact with the aging process to increase the risk of age-related diseases. The research aims to determine if long-term CSD affects the...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $167,940 project grant to The Children's Hospital Corporation (Boston Children's Hospital) to elucidate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease. The project, awarded on August 15, 2025, aims to (1) determine if the MEF2 transcription factors mediate survival of specific neuronal subtypes vulnerable to Alzheimer's pathology, (2) assess whether...
- The National Institute on Aging awarded $3,391,684 under the Aging Research grant program (CFDA 93.866) to Texas A&M University Health Science Center from May 1, 2022 to April 30, 2025. The project aims to test the hypothesis that peripheral insulin-like growth factor-1 (IGF-1), delivered intraperitoneally or orally, will improve acute stroke disability as well as chronic depressive-like behaviors and cognitive impairment post-stroke in a rodent model. Researchers also expect peripheral...
The National Institute on Aging, through the Aging Research Federal Grant Program (CFDA 93.866), awarded $450,250.00 to George Washington University on August 15, 2025 to conduct a project titled "The Impact of Early Life Stress on Vascular Aging". The project aims to explore how early life stress and adversity contribute to cardiovascular disease risk in adulthood using a preclinical mouse model. Specifically, the project will (1) evaluate the effects of early life adversity on vascular structure and function in adulthood, and (2) investigate vascular molecular changes in adulthood due to early life adversity. This research is intended to advance the understanding of how early life stress influences adult cardiovascular disease risk, identify potential sex-specific vascular markers, and provide insights into therapeutic targets for cardiovascular disease linked to early-life adversity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $450.3k | 8/6/25 |