Project Grant R21AG093719
- Federal Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a $3.28 million Project Grant to Harvard T.H. Chan School of Public Health on September 15, 2025, with completion targeted for August 31, 2029. This research initiative addresses the interplay between herpesvirus infection, immune responses, apolipoprotein E (APOE) genotype, and tau-pathology development in Alzheimer's disease (AD). The primary deliverable is scientific...
- Federal Project Grant Award Summary The National Institute on Aging (part of the Aging Research program, CFDA 93.866) awarded the University of Southern California a $3.35 million Project Grant on September 15, 2025, to conduct research on regulated cGAS activation in herpes simplex virus type 1 (HSV-1)-associated neuropathogenesis. The research addresses the molecular mechanisms linking HSV-1 infection to Alzheimer's disease and related dementias by investigating how cytosolic DNA activates the...
- Federal Grant Award Summary The National Institute on Aging awarded The Trustees of Columbia University in the City of New York a Project Grant totaling $529,744 under the Aging Research program (CFDA 93.866) effective February 15, 2026, with a completion date of January 31, 2031. This five-year award supports biomedical research investigating the mechanisms of Alzheimer's disease progression through the entorhinal cortex-hippocampal circuit. The research will generate scientific knowledge...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of South Florida $3.297 million under the Aging Research program (CFDA 93.866) for a four-year project period (September 1, 2025 – August 31, 2029) to develop novel peptidomimetic biomaterials that inhibit amyloid-beta (Aβ42) aggregation in Alzheimer's disease. The research deliverables include the rational design and characterization of structurally related analogues to a lead compound that stabilizes Aβ...
- Federal Grant Award Summary Baylor College of Medicine received a $3.04 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of July 31, 2029. The grant funds research investigating the relationship between SARS-CoV-2 (COVID-19) infection and the initiation and acceleration of Alzheimer's disease (AD) and related dementias (AD/RD), including Pick's disease, frontotemporal dementia, and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $2,557,950 to The Feinstein Institutes for Medical Research under the Aging Research program (CFDA 93.866) on May 15, 2026, for research investigating the role of neurotoxic astrocytes in Alzheimer's disease (AD) pathogenesis. This R01 Project Grant, which extends through April 30, 2030, focuses on elucidating a novel molecular mechanism whereby extracellular cold-inducible RNA-binding protein (ECIRP) induces...
- Federal Project Grant Award Summary New York University School of Medicine received a $712,578 project grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion targeted for December 31, 2030. The grant funds a prospective epidemiological study investigating the relationship between viral infections and the subsequent risk of Alzheimer's disease (AD) in aging populations. The research addresses significant...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $1.08 million Project Grant to The Johns Hopkins University on August 1, 2025, under the Aging Research program (CFDA 93.866) to develop adeno-associated virus (AAV) vectors for selective manipulation of oligodendrocyte precursor cells (OPCs). The two-year project, concluding July 31, 2027, will generate novel OPC-selective AAV vectors and utilize them to investigate whether reactive transformation of OPCs surrounding...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $2,957,210 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025, for research extending through August 31, 2029, under the Aging Research program (CFDA 93.866). The project, titled "Deciphering the Role of CD44 Astrocytes in Alzheimer's Disease," delivers comprehensive biomedical research aimed at understanding the molecular...
The National Institute on Aging (NIA) awarded a Project Grant of $442,485 to the University of Colorado-Denver for the period of June 1, 2026 through May 31, 2028 under the Aging Research program (CFDA 93.866). This award supports research investigating the selective vulnerability of the locus coeruleus and hypothalamus to herpes simplex virus type 1 (HSV-1) infection in Alzheimer's disease progression. The project deliverables include advanced spatial transcriptomics and proteomics analyses using the NanoString GeoMx digital spatial profiler platform, in vivo electrophysiological monitoring via electroencephalography and local field potential recordings, and behavioral assessments utilizing specialized feeding devices to characterize molecular and functional alterations in disease-relevant brain regions. The research program comprises two primary aims focused on delineating spatial and temporal molecular changes in targeted brain structures following intranasal HSV-1 infection in transgenic Alzheimer's disease mouse models and wild-type controls, and subsequently linking identified molecular pathologies to functional outcomes through integrated neurophysiological and behavioral monitoring. This multidisciplinary approach is designed to elucidate early transcriptional and post-translational mechanisms underlying HSV-1-induced amyloid-beta and tau pathology formation, microglial activation, and associated neuroinflammatory responses that may accelerate cognitive and non-cognitive disease manifestations in Alzheimer's disease progression.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.5k | 5/29/26 |