Project Grant RF1AG091371
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $839,933 under the Aging Research program (CFDA 93.866) commencing September 1, 2025, and concluding May 31, 2030. This award supports research investigating the role of N6-methyladenosine (M6A) RNA modifications in microglial dysfunction and Alzheimer's disease pathogenesis. The research will systematically map M6A RNA modification landscapes in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a $2.96M Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025, with completion targeted for August 31, 2029. This research project aims to decipher the role of CD44 astrocytes in Alzheimer's disease (AD) pathology. The research will produce scientific findings and experimental outcomes regarding how...
- Summary Duke University's Office of Research Administration received a $509,413 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025, with completion scheduled for May 31, 2030. The grant supports research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD). The project delivers scientific research and analysis focused on understanding how m6A (N6-methyladenosine)...
- Summary of Federal Project Grant Award The National Institute on Aging (NIA) awarded $454,937 to The Research Foundation For The State University Of New York (Stony Brook University) under the Aging Research program (CFDA 93.866) on February 15, 2026, for a project period extending through January 31, 2028. The award supports research entitled "Regulatory Landscape of Neurodegeneration by Single-Cell Spatial Multiomics," which addresses critical gaps in understanding Alzheimer's...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas Medical Branch at Galveston $1,112,821 under the Aging Research program (CFDA 93.866) for a five-year project period spanning January 1, 2026, through December 31, 2030. This Project Grant supports biomedical research investigating the interplay between microglia activation and tau oligomer polymorphs in cognitive resilience among Alzheimer's disease patients. The research focuses on...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded New York University School of Medicine a $3.1 million Project Grant on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the relationship between peripheral immune dysfunction and vascular contributions to cognitive decline and dementia. The research integrates blood biomarker analysis—specifically measuring platelet aggregation, neutrophil activity, and proteomic data—with advanced magnetic...
- Federal Grant Award Summary The National Institute on Aging awarded J. David Gladstone Institutes a Project Grant in the amount of $790,288 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of November 30, 2030. The award funds genetic research aimed at dissecting the 17q21.31 MAPT (Microtubule-Associated Protein Tau) locus to identify disease drivers underlying Alzheimer's disease and related neurodegenerative conditions. The research addresses the...
- Federal Project Grant Summary Award Details: The National Institute on Aging (NIA) awarded Brigham and Women's Hospital Inc. a $6.47 million R01 Project Grant under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2030, to support the Ante-Amyloid Treatment of Alzheimer's Disease (A3) Trial and the Alzheimer Plasma Extension (APEX) Study. The A3 Trial represents a Phase IIb prevention study testing low-dose lecanemab, a monoclonal antibody targeting...
- Federal Project Grant Award Summary The Trustees of Columbia University in the City of New York, Health Sciences Division, received a $529,744 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct neuroscience research investigating the mechanisms underlying Alzheimer's disease progression. The award, initiated February 15, 2026, and extending through January 31, 2031, supports research focused on understanding why the entorhinal cortex is...
The National Institute on Aging (NIA) awarded The Feinstein Institutes for Medical Research a Project Grant (R01) of $2,557,950 beginning May 15, 2026, through April 30, 2030, under the Aging Research program (CFDA 93.866). The grant funds research to investigate the molecular mechanisms by which extracellular cold-inducible RNA-binding protein (ECIRP) induces neurotoxic astrocytes and their role in Alzheimer's disease (AD) pathogenesis. The research deliverables include characterization of ECIRP's interaction with the triggering receptor expressed on myeloid cells-1 (TREM-1) pathway, evaluation of ECIRP as a biomarker in AD patients, and assessment of a designed anti-ECIRP peptide therapeutic (M3) for preventing neurotoxic astrocyte activation in both in vitro and in vivo models. This translational research initiative aims to establish causative links between neurotoxic astrocytes and AD progression while developing a potential therapeutic intervention targeting ECIRP-induced neuroinflammation. The research addresses AD as the fifth leading cause of death in the United States and seeks to generate scientific knowledge regarding disease mechanisms and therapeutic targets that could inform future treatment strategies for neurodegenerative dementia.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 5/7/26 |