Project Grant RF1AG091410
- This $3,039,032 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports research on the potential links between SARS-CoV-2 infection and the initiation or acceleration of Alzheimer's disease and related dementias. The Baylor College of Medicine, a prestigious research institution in Texas, will conduct this work from August 2025 through July 2029. The key objectives are to investigate: (1) the relative contributions of genetic risk factors and...
- The National Institute on Aging (NIA) awarded a $1,281,004 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The University of North Carolina at Charlotte to investigate the interactions between viral infection, tau pathology, and neuroinflammation. The 3-year research project aims to determine whether viral infection increases tau pathology, assess the impact of tau aggregation on viral replication, and examine the effect of tau pathology on the neuroinflammatory...
- This Project Grant award of $125,901 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to determine the role of alternative polyadenylation (APA) in neurodegenerative diseases like Alzheimer's and Parkinson's. The primary awardee, President and Fellows of Harvard College (doing business as Harvard Medical School), will repurpose 3'-biased single-nucleus RNA-sequencing data from over 350 post-mortem human brain samples to map APA at the single-cell level in these...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
- This $784,596 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models. The project aims to develop a proteogenomic pipeline to globally characterize disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavages across multiple brain...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This federal Project Grant award of $459,250.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is focused on investigating the impact of stress and resilience on the longitudinal trajectories of Alzheimer's disease (AD)-related brain pathology and cognitive function. The research aims to elucidate the mechanisms by which stress may predispose individuals to long-term cognitive changes and the development of AD. The awardee, The General Hospital...
- This $788,121 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will fund a 5-year cross-sectional, longitudinal, and observational study to investigate the impact of Alzheimer's disease (AD) risk genes, with a focus on APOE E4, on brain function in HIV-positive older Black/African American adults. The study aims to increase understanding of Alzheimer's disease and related dementias (ADRD) risk factors in this vulnerable population, who face an increased...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $1,550,462 to support a 5-year cross-sectional, longitudinal, and observational study investigating the impact of Alzheimer's disease (AD) risk genes, with a focus on APOE E4, on brain function in older Black/African American individuals living with HIV. The project aims to enroll 120 participants with HIV (60 with and 60 without the APOE E4 allele) and 80 demographically...
This Project Grant award of $3,280,861, provided by the National Institute on Aging (CFDA 93.866 Aging Research), will support a comprehensive study investigating the interplay between herpesvirus infection, immune responses, APOE genotype, and the development of tau-pathology as it relates to Alzheimer's disease (AD). The research will leverage the Nurses' Health Study, a longitudinal cohort of over 100,000 women, to analyze archived samples for tau-pathology biomarkers and immune responses. The goal is to clarify the role of microbial infections, particularly herpesviruses, in triggering AD pathology. The award was made to the President and Fellows of Harvard College, Harvard T.H. Chan School of Public Health, and runs from Sep 15, 2025 to Aug 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 9/8/25 |