Project Grant RF1AG088625
- The University of Southern California (USC) was awarded a $4,975,336 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop advanced magnetic resonance imaging (MRI) techniques for mapping and quantifying cerebral small vessels as imaging biomarkers of vascular cognitive impairment and dementia (VCID). The project aims to optimize acquisition protocols and analysis pipelines for black-blood and arterial spin labeling MRI at 3 Tesla to comprehensively...
- This $3,039,032 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports research on the potential links between SARS-CoV-2 infection and the initiation or acceleration of Alzheimer's disease and related dementias. The Baylor College of Medicine, a prestigious research institution in Texas, will conduct this work from August 2025 through July 2029. The key objectives are to investigate: (1) the relative contributions of genetic risk factors and...
- This federal Project Grant award for $369,823 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate how SARS-CoV-2 infection and the viral S1 protein may induce cellular senescence in the brain and contribute to the development of Alzheimer's disease. Key research activities include studying the impact of the S1...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to conduct research on the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The 5-year project aims to leverage experimental mouse models, molecular characterization of endogenous retroviruses, and human induced pluripotent stem cell models to investigate...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $831,235 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Southern California (USC) to explore a key nucleotide synthesis enzyme as a potential target for developing broad-spectrum antiviral therapies. The project, led by Co-PIs Pinghui Feng and Chao Zhang, aims to genetically interrogate the enzyme's role in viral immune evasion and metabolic reprogramming...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Southern California provides $622,401 over 5 years starting January 1, 2025 to research causal models of brain biomarker changes leading to Alzheimer's disease and related dementias (ADRD). The project aims to: 1) fit novel deep learning models to predict ADRD pathology from diffusion MRI data, 2) generate individualized brain morphology prediction maps as "digital...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,083,046 Project Grant under the Aging Research program (CFDA 93.866) to The Johns Hopkins University. The grant, running from August 1, 2025 to July 31, 2027, will support the development of novel adeno-associated viruses (AAVs) to selectively manipulate oligodendrocyte precursor cells (OPCs) in the central nervous system. The project aims to test the hypothesis that reactive...
- This Project Grant award of $3,280,861, provided by the National Institute on Aging (CFDA 93.866 Aging Research), will support a comprehensive study investigating the interplay between herpesvirus infection, immune responses, APOE genotype, and the development of tau-pathology as it relates to Alzheimer's disease (AD). The research will leverage the Nurses' Health Study, a longitudinal cohort of over 100,000 women, to analyze archived samples for tau-pathology biomarkers and immune responses....
- This federal Project Grant award, totaling $215,810.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to identify host proteins degraded in neurons by the Herpes Simplex Virus (HSV-1) and the roles of the viral proteins ICP0 and PUL55/PUL13/PUS10 in protein degradation and viral reactivation from latent infection. The primary awardee is the Rector &...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
The University of Southern California has been awarded a $3,354,022 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on "Regulated cGAS Activation in HSV-1-Associated Neuropathogenesis." The 4-year project, running from September 2025 to August 2029, aims to investigate the role of cytosolic DNA-mediated activation of the cGAS pathway and its regulation by a metabolic enzyme in the development of Alzheimer's disease and related dementias associated with Herpes Simplex Virus-1 (HSV-1) infection. The research is expected to provide molecular insights into the mechanisms by which HSV-1, a ubiquitous human pathogen, contributes to neurodegeneration and cognitive decline, thereby advancing scientific understanding of Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.4m | 9/5/25 |