Project Grant RF1NS144213
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will fund research to investigate whether SARS-CoV-2 proteins can accelerate the development of Alzheimer's disease pathology in fly and mouse models. The $419,375 award to the University of Florida will support a 2-year study to screen SARS-CoV-2 proteins and assess their effects on Alzheimer's-related amyloid-beta aggregation and neurodegeneration. The research aims to elucidate...
- The National Institute on Aging (NIA) awarded a 3-year, $2,561,480 Project Grant (CFDA 93.866) to Brigham & Women's Hospital to study the post-acute sequelae of SARS-CoV-2 infection (PASC) and subsequent disease progression in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) and related dementias (ADRD). The project aims to: 1) understand the epidemiology of PASC in cognitively impaired individuals; 2) examine the impacts of COVID-19 and PASC on disease...
- This federal Project Grant award for $369,823 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate how SARS-CoV-2 infection and the viral S1 protein may induce cellular senescence in the brain and contribute to the development of Alzheimer's disease. Key research activities include studying the impact of the S1...
- This Project Grant award of $2,549,080.00, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the impact of SARS-CoV-2 infection on the cerebrovasculature as a risk factor for vascular contributions to cognitive impairment and dementia (VCID). The award, with a performance period from August 11, 2025 to July 31, 2029, will fund the University of Illinois to: Determine how prior SARS-CoV-2 infection influences...
- This Project Grant award of $3,280,861, provided by the National Institute on Aging (CFDA 93.866 Aging Research), will support a comprehensive study investigating the interplay between herpesvirus infection, immune responses, APOE genotype, and the development of tau-pathology as it relates to Alzheimer's disease (AD). The research will leverage the Nurses' Health Study, a longitudinal cohort of over 100,000 women, to analyze archived samples for tau-pathology biomarkers and immune responses....
- This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to conduct research on the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The 5-year project aims to leverage experimental mouse models, molecular characterization of endogenous retroviruses, and human induced pluripotent stem cell models to investigate...
- This $3,264,260 Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research) aims to determine whether olfactory impairment caused by exposure to ambient fine particulate matter (PM2.5) pollution is a causal factor in the development of late-onset dementia, including Alzheimer's disease. The award will fund a comprehensive research project conducted by the University of Maryland, Baltimore to investigate the role of the cGAS/STING/IKK2/NF-κB inflammatory...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
This $3,039,032 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports research on the potential links between SARS-CoV-2 infection and the initiation or acceleration of Alzheimer's disease and related dementias. The Baylor College of Medicine, a prestigious research institution in Texas, will conduct this work from August 2025 through July 2029. The key objectives are to investigate: (1) the relative contributions of genetic risk factors and COVID-19 on the onset and progression of Alzheimer's and related dementias, (2) the effects of SARS-CoV-2 variants on these neurodegenerative processes, and (3) the impacts of prior infections with other common viruses like HSV-1. This research aims to improve understanding of the complex etiological factors underlying Alzheimer's disease in the context of the COVID-19 pandemic.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 8/14/25 |