Project Grant R01AG092405
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $3.26 million Project Grant to the University of Maryland, Baltimore on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate olfactory dysfunction as a predictor of fine particulate matter (PM2.5) exposure progression to dementia. The research will be conducted over a 47-month period (September 2025 through August 2029) and will deliver comprehensive scientific research aimed at...
- Federal Grant Award Summary The Monell Chemical Senses Center received a $532,348 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 20, 2025, with completion targeted for May 31, 2030. The award funds the Monell Scientist Entrepreneurial Program for Healthy Aging (MSEP-HA), an educational initiative that develops standardized smell tests as biomarkers for neurodegenerative diseases such as Alzheimer's disease. The program...
- Federal Grant Award Summary The National Institute on Aging awarded a $589,154 Project Grant to the University of Maryland, Baltimore, effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award supports the development and validation of a normalized cerebrovascular reactivity (NCVR) magnetic resonance imaging technique designed to improve detection of cerebral vascular dysfunction in patients with small-vessel-disease-related cognitive...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a $622,086 project grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research investigating microglial NOD2/RIPK2 (nucleotide-binding oligomerization domain-containing protein 2/receptor-interacting serine/threonine-protein kinase 2) signaling in Alzheimer's disease (AD) pathophysiology. The research project, with an anticipated completion date of February...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a $1.6 million Project Grant effective June 1, 2025, through February 28, 2030, under the Aging Research program (CFDA 93.866). This research initiative investigates the dysfunction of brain microvascular and lymphatic vessels in obesity-linked cognitive impairment. The project will develop and apply newly created magnetic resonance imaging (MRI) techniques to provide non-invasive...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $529,744 Project Grant effective February 15, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). The award funds research investigating the mechanisms driving Alzheimer's disease progression through the entorhinal cortex-hippocampal circuit. The primary deliverables include longitudinal scientific investigations utilizing two-photon in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $127,224 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support scientific investigation into the pathological mechanisms of Alzheimer's disease (AD). The project, which extends through August 31, 2028, will elucidate the role of s-nitrosylated phospholipase D3 (SNO-PLD3) in microglial and neuronal pathophysiology associated with AD. Specifically,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a $1,459,072 Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to investigate inhibitory neuron dysfunction in Alzheimer's disease (AD). The research will develop and implement innovative methodologies to monitor and manipulate two distinct inhibitory interneuron cell populations—parvalbumin (PVALB) and somatostatin (SST) cells—in both wildtype and AD-knock-in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $1.85M project grant effective June 1, 2025, through March 31, 2030, under the Aging Research program (CFDA 93.866). The research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the biological mechanisms linking early brain development to Alzheimer's disease (AD) pathology in later life. The project will deliver empirical research...
- Federal Grant Award Summary The National Institute on Aging awarded a $2.49 million Project Grant to the University of California, Irvine under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award supports fundamental research investigating circuit vulnerability of the lateral and medial entorhinal cortices in tauopathy models relevant to Alzheimer's disease (AD). The project will utilize two tau mouse models to identify entorhinal...
The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a $649,766 Project Grant effective March 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research grant funds a comprehensive five-year investigation examining how hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate olfactory dysfunction in aging and Alzheimer's disease. The project delivers scientific research services spanning molecular and cellular biology, neurophysiology, and behavioral neuroscience, with the overarching objective of identifying the mechanisms by which HCN channel downregulation disrupts olfactory bulb output neuron function and impairs olfactory performance in aged and disease-affected populations. The research program encompasses four integrated aims progressing from gene expression analysis to circuit-level neural activity characterization to behavioral outcomes. Deliverables include quantitative analyses of HCN4 channel expression and ion conductance changes during aging and in a familial Alzheimer's disease mouse model; electrophysiological recordings demonstrating correlations between HCN channel decline and altered olfactory bulb neural activity; pharmacological studies replicating aging-related network disruptions in young animals; and behavioral assessments linking HCN channel dysfunction to olfactory performance deficits. This research contributes to the National Institute on Aging's mission to advance understanding of aging processes and age-related neurological diseases through biomedical investigation and supports the development of potential therapeutic strategies for olfactory loss associated with neurodegeneration.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $649.8k | 2/18/26 |