Project Grant R56AG091682
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $498,748.00 to the University of Massachusetts Medical School (UMass Medical) to elucidate the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The project aims to investigate the effects of deleting other MS4A family members, individually or in combination, on neurodegenerative phenotypes in mouse models. Additionally, the research will...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $129,330 Project Grant to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on profiling and forecasting individual progression in Alzheimer's disease and related dementias (ADRD). The key objectives of this 5-year project are to: 1) deploy a multi-modal information framework that leverages decades-long in vivo and digital...
- This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
- This federal Project Grant award of $441,612 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University (Boston University Medical Campus) supports research to evaluate the use of digital cognitive measures, such as digital pen tasks and voice recordings, to monitor early cognitive decline in relation to modifiable Alzheimer's disease risk factors. The project aims to leverage the Framingham Heart Study's longitudinal data on digital cognitive...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This Project Grant award of $4,787,820.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a better understanding of the individual- and system-level characteristics that influence diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), and how diagnosis can moderate the effects of cognitive decline on employment, future care, and quality of life. The key objectives are to: 1) examine whether older adults experiencing...
- This federal Project Grant award for $831,583 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on "Characterizing Microvascular Impairment in Adults with Elevated Genetic Risk for Alzheimer's Disease." The project aims to elucidate the physiological mechanisms by which the APOE-E4 genetic risk factor contributes to microvascular impairment,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
This Project Grant award of $643,089 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to assess medication self-administration (MSA) as an early indicator of cognitive impairment and Alzheimer's disease and related dementias (ADRD). The research will be conducted by the University of Massachusetts Medical School (UMASS Medical) from September 2025 to August 2026. The key objectives are to: 1) cross-sectionally associate MSA errors and self-overestimation with behavioral and brain-based ADRD biomarkers, 2) associate MSA assessment with cognitive decline trajectories, and 3) determine if MSA predicts greater care needs and disability. This will be done through an objective MSA assessment of an estimated 1,185 participants from the Framingham Heart Study cohort, which has well-characterized cognitive data spanning decades.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $643.1k | 9/25/25 |