Project Grant K08AG086586
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- The National Institute on Aging (NIA) awarded a $188,892 Project Grant (CFDA 93.866 - Aging Research) to the University of Washington to investigate microglial subpopulations that may contribute to resilience against Alzheimer's disease (AD). The goal is to 1) address key gaps in understanding microglial subpopulation responses in resilient individuals, and 2) develop tools and model systems to manipulate specific microglial subpopulations. The researcher will evaluate microglial...
- This federal Project Grant award of $459,250.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is focused on investigating the impact of stress and resilience on the longitudinal trajectories of Alzheimer's disease (AD)-related brain pathology and cognitive function. The research aims to elucidate the mechanisms by which stress may predispose individuals to long-term cognitive changes and the development of AD. The awardee, The General Hospital...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $804,450 Project Grant to the J. David Gladstone Institutes in San Francisco, CA. This grant, awarded on June 1, 2025, will fund a research project titled "Targeting NELL2 and GABAergic Dysfunction to Mitigate APOE4-Driven Pathogenesis in Alzheimer's Disease." The project aims to investigate the role of the APOE4 gene and its interaction with sex and aging in contributing to...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,249,957 Project Grant under CFDA 93.866 (Aging Research) to Advantage Therapeutics, Inc. in Florida. The grant aims to perform IND-enabling studies on a small molecule that is disease-modifying, low-cost, and has a long safety record for the treatment of Alzheimer's disease. The proposed molecule is designed to reduce brain inflammation and restore phagocytosis, thereby improving the...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $131,813 Project Grant to the Trustees of Boston University (Boston University Medical Campus) on May 1, 2025. The grant aims to evaluate the effects of poverty alleviation policies, such as the Supplemental Nutrition Assistance Program (SNAP), on the risk and disparities of Alzheimer's disease and related dementias (AD/ADRD). The research will leverage data from the Health and...
- This federal Project Grant award for $831,583 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on "Characterizing Microvascular Impairment in Adults with Elevated Genetic Risk for Alzheimer's Disease." The project aims to elucidate the physiological mechanisms by which the APOE-E4 genetic risk factor contributes to microvascular impairment,...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $167,940 project grant to The Children's Hospital Corporation (Boston Children's Hospital) to elucidate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease. The project, awarded on August 15, 2025, aims to (1) determine if the MEF2 transcription factors mediate survival of specific neuronal subtypes vulnerable to Alzheimer's pathology, (2) assess whether MEF2 activation may be protective, and (3) leverage human single-nucleus transcriptomic data to study molecular mechanisms of resilience in humans. This research builds on the investigators' prior discovery that environmental enrichment increases MEF2 activity in cortical neurons and that MEF2 overexpression alone can induce cognitive resilience in a mouse model of neurodegeneration. The project will run through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/2/25 | ||
| Not listed | $167.9k | 8/8/25 |