Project Grant RF1NS140600
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
- This federal Project Grant award of $836,992.00, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research to investigate the effects of military-associated environmental toxins on motor neurons and glial cells in sporadic amyotrophic lateral sclerosis (ALS) at the University of Massachusetts Medical School (UMMS) in Worcester, MA. The research aims to transform healthcare for military service members, veterans, and the...
- This $461,900 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to study the mechanisms underlying TDP-43 dependent structural deficits in amyotrophic lateral sclerosis (ALS) muscles. The project, conducted by the Pennsylvania State University, aims to investigate how TDP-43, a protein involved in ALS and other neurodegenerative disorders, affects muscle function and structure. The research will utilize non-canonical amino acid...
- This Project Grant award of $426,313, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research at The Johns Hopkins University to investigate the signaling pathways that disrupt neurofilament (NF) phosphorylation dynamics and lead to NF hyperphosphorylation, a pathology associated with neurodegenerative diseases such as amyotrophic lateral...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This Project Grant award of $387,525 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the role of proton-mediated signaling at the neuromuscular junction in amyotrophic lateral sclerosis (ALS) models. The research aims to study how dysregulation of extracellular proton (pH) concentrations may contribute to the progression of ALS in...
- This Project Grant award of $129,717 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of neutrophils in the pathology of amyotrophic lateral sclerosis (ALS). The research, conducted by the Regents of the University of Michigan, aims to identify neutrophil subpopulations and mechanisms associated with ALS progression and...
- This Project Grant award of $460,625 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to investigate the roles of the deubiquitylation pathway in TDP-43 pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research is being conducted by the University of Massachusetts Medical School (UMMS) and...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,275,512 to The Regents of the University of California, San Francisco (UCSF) to conduct research on understanding how changes in progranulin (PGRN) protein species impact the accumulation of the TDP-43 protein, which is associated with neurodegenerative disorders like Alzheimer's disease and frontotemporal dementia. The research aims to elucidate the role of lysosomes and lysosomal...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $921,822 to Yale University to conduct research on the role of the TBK1 gene and its effects on lysosome function in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research aims to elucidate the molecular mechanisms by which TBK1 coordinates lysosome function with cellular demand, including examining the contributions of TBK1...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of the actin-binding protein profilin-1 (PFN1) in the pathogenesis of amyotrophic lateral sclerosis (ALS). The $3,323,710 award to the University of Massachusetts Medical School will fund two primary aims: 1) Interrogating the hypothesis that mutant PFN1 impairs autophagy and vesicular degradation through interactions with phosphatidylinositol 3-phosphate (PI3P) and other phosphoinositides in ALS-relevant cell types, and 2) Conducting biophysical binding and structural analyses of PIP/PFN1 complexes within biologically relevant membrane contexts. This research aims to elucidate the mechanisms underlying PFN1-mediated neurodegeneration in ALS, with the goal of identifying potential therapeutic targets. The award period runs from Aug 15, 2025 to Jul 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 8/8/25 |