Project Grant R21AG089706
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $803,111 to The Trustees of the University of Pennsylvania to model and contrast the progression of neuroinflammation, abnormal iron accumulation, and neurodegeneration in frontotemporal lobar degeneration (FTLD) with tau (FTLD-tau) versus TDP-43 (FTLD-TDP) pathology. The award supports a multidisciplinary approach to comprehensively study glial activation and iron dysregulation in human brain...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $791,086 aims to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes, such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The project will leverage data from autopsy-confirmed datasets, in vivo neuroimaging, and clinical assessments to build...
- This $3,360,074 federal Project Grant was awarded on September 15, 2025 by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant is funding research led by the University of Pennsylvania to develop short RNA therapeutics that can combat TDP-43 proteinopathy, a key pathological feature of several devastating neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The research aims to...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $786,632 to Northwestern University to conduct research on the neuropathological, molecular, and clinical features of frontotemporal lobar degeneration with transactive response DNA-binding protein type C (FTLD-TDP type C). The award period runs from December 1, 2024 to November 30, 2029. The research aims to expand on previous discoveries made by the Northwestern Primary...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This federal Project Grant award of $3,188,901.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the relationships between in-vivo biomarkers for amyloid, tau, and neurodegeneration (ATN), neuropsychiatric symptoms, vascular risk factors, and genetic risks in Alzheimer's disease. The study will leverage data from large research cohorts like the Alzheimer's Disease Neuroimaging Initiative to develop and optimize machine learning models that can...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
This Project Grant award, titled "Integrated Micro-to-Macro Network Models of Disease Spread in Frontotemporal Dementia", is funded by the National Institute on Aging (CFDA 93.866 - Aging Research) for $427,919. The award will be performed by The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, from August 15, 2025 to July 31, 2027. The goal of this project is to develop a multi-scale network model that integrates microscopic histopathology imaging and macroscopic in vivo magnetic resonance (MR) imaging data to characterize the unique patterns of Frontotemporal Lobar Degeneration (FTLD) tau and FTLD TDP-43 pathologies. Specifically, the project aims to (1) integrate microscopic and macroscopic neuroimaging data into a shared multi-scale network framework, and (2) develop a novel cellular network model for multiplex immunofluorescent imaging data. The intent is to leverage this integrated, high-dimensional network modeling approach to improve the diagnosis and understanding of these two distinct FTLD pathologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.9k | 8/7/25 |