Project Grant RF1AG087271
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
- This federal Project Grant award of $3,080,520.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to develop novel biomarkers for the early detection of Alzheimer's disease and related dementias (ADRD) using resting-state functional magnetic resonance imaging (rs-fMRI) data and machine learning. The research aims to address limitations of current ADRD biomarkers by leveraging the dynamics of functional connectivity networks and accounting for heterogeneity...
- This $1,012,879 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University (NYU) to develop three novel statistical machine learning methods for Alzheimer's disease (AD) research using multi-view imaging, genomic, and clinical data. The specific aims include: 1) developing a multi-view data decomposition method to construct brain and genomic networks across AD statuses, 2) developing an optimal false discovery rate control method to...
- This federal Project Grant award of $817,357 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to harness novel machine learning approaches for behavioral segmentation and brain signal integration in humanized models of Alzheimer's disease. The key products and services to be delivered under this grant include: Further validation of the grantee's "Variational Animal Motion Embedding (VAME)" machine learning platform for comprehensive behavioral phenotyping of...
- This federal Project Grant award of $372,690, provided by the National Institute on Aging (CFDA 93.866 Aging Research), aims to comprehensively understand the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The key objectives are to: (1) develop new statistical methods for uncovering heterogeneous causal relationships among amyloid-beta, tau accumulation, and cognition across diverse AD datasets; (2) apply these methods to reveal optimal treatment windows and target populations...
- The federal Project Grant award of $3,642,232.00, awarded on August 5, 2025 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to leverage genetics and multi-omic data to identify causal genes, cell types, and molecular mechanisms underlying Alzheimer's disease (AD). The project, titled "UNRAVELING THE GENETIC BASIS OF MOLECULAR FUNCTIONS IN ALZHEIMER'S DISEASE", will integrate multi-ancestry molecular quantitative trait loci (xQTL) data...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $791,086 aims to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes, such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The project will leverage data from autopsy-confirmed datasets, in vivo neuroimaging, and clinical assessments to build...
- This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $770,558 project grant to Wake Forest University Health Sciences (WFUHS) to establish connections between Alzheimer's disease (AD)-related genomic markers and neuroimaging phenotypes. The objective is to determine the heterogeneity of AD subtypes and their association with the clinical onset of dementia. The project aims to develop data-driven computational models using multi-modal...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
This federal Project Grant award of $3,188,901.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the relationships between in-vivo biomarkers for amyloid, tau, and neurodegeneration (ATN), neuropsychiatric symptoms, vascular risk factors, and genetic risks in Alzheimer's disease. The study will leverage data from large research cohorts like the Alzheimer's Disease Neuroimaging Initiative to develop and optimize machine learning models that can predict neuropsychiatric phenotypes and genotypes from these multivariate ATN biomarkers. The 4-year project, starting September 1, 2025, will generate harmonized data resources and advanced analytical techniques to investigate the heterogeneity of Alzheimer's disease pathology and symptoms. This comprehensive research effort seeks to improve understanding of the underlying neurobiological mechanisms and ultimately enhance outcomes for patients with Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 8/26/25 |