This $603,031 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports a 1-year research study on the clinical, cellular, and pathological features of comorbid Alzheimer's disease and TDP-43 proteinopathies in elderly patients with amnestic dementia. The key objectives are to: 1) identify the shared versus distinct clinical, neuropsychological, and psychiatric characteristics of this condition; 2) determine the cellular...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $2,398,069 Project Grant to The Trustees of the University of Pennsylvania for the project "Pathology-Guided Biofluid Biomarker Strategies for Classification and Progression of Frontotemporal Lobar Degeneration (FTLD)." The project aims to develop multi-analyte algorithms to screen for and provide prognosis of FTLD, a family of neurodegenerative proteinopathies, by...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,138,538 to Mayo Clinic Jacksonville to expand research into the mechanisms underlying frontotemporal lobar degeneration (FTLD), which causes frontotemporal dementia (FTD) and is genetically linked to amyotrophic lateral sclerosis (ALS). The research aims to investigate key...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Case Western Reserve University provides $442,750 to develop synthetic replicas of TDP-43 protein filaments associated with frontotemporal dementia and amyotrophic lateral sclerosis. The goal is to establish in vitro conditions for generating amyloid fibrils with structures identical to brain-derived TDP-43 filaments, which would enable mechanistic studies on disease-relevant aggregation pathways...
This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,275,512 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the impact of progranulin species on TDP-43 proteolysis and pathobiology in neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementia, and limbic-predominant, age-associated TDP-43 encephalopathy. The research aims to determine how progranulin species contribute to TDP-43...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $803,111 to The Trustees of the University of Pennsylvania to model and contrast the progression of neuroinflammation, abnormal iron accumulation, and neurodegeneration in frontotemporal lobar degeneration (FTLD) with tau (FTLD-tau) versus TDP-43 (FTLD-TDP) pathology. The award supports a multidisciplinary approach to comprehensively study glial activation and iron dysregulation in human brain...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This federal Project Grant award of $1,076,760 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the genetic underpinnings and disease mechanisms of frontotemporal lobar degeneration (FTLD), a group of neurodegenerative disorders affecting personality, cognition, and communication. The key products and services to be delivered under this 5-year award include: 1) Developing a novel "humanized" mouse model of FTLD by transplanting...
This Project Grant award of $638,682 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the role of liquid-liquid phase separation (LLPS) of the TDP-43 protein and its interactions with mitochondria in neurodegenerative diseases. The research aims to systematically examine how LLPS regulates TDP-43 localization to mitochondria, and how this contributes to TDP-43-induced mitochondrial dysfunction and neuronal loss, using...
This $3,841,367 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to better understand the role of the TBK1 protein kinase and associated autophagy pathways in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The University of California, San Francisco (UCSF) will use advanced stem cell models and proteomics to: 1) identify novel TBK1 substrates and characterize the effects of TBK1 loss on...