The federal Project Grant award R01AG090414, with a total funding of $803,111.00, was awarded to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, by the National Institute on Aging (CFDA 93.866 Aging Research program).
The grant supports a comprehensive research effort to model and contrast the microscopic, mesoscopic, and macroscopic progression of neuroinflammation, abnormal iron accumulation, and neurodegeneration in human brain tissue from patients with frontotemporal lobar degeneration (FTLD) with tau (FTLD-tau) versus FTLD with TDP-43 (FTLD-TDP) pathology. The research aims to provide critical insights into the role of glia and iron homeostasis in the spread of tau and TDP-43 proteinopathies, and to guide the development of MRI biomarkers for these conditions. The award will fund this work over a period of approximately 5 years, from the start date of December 15, 2024 through the ultimate completion date of November 30, 2029.
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