This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $450,688 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the molecular and metabolic changes that occur in cardiometabolic tissues during the menopausal transition in women. The key objectives are to: 1) Identify menopause-induced changes in chromatin accessibility and gene expression in mouse liver, adipose, and aorta tissues, comparing...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting comprehensive scientific investigations into the biological, clinical, and sociobehavioral aspects of aging and age-related health conditions, with a focus on understanding the mechanisms of Alzheimer's disease (AD) and developing potential therapeutic approaches. The $2,114,698 grant, awarded to the University of North Texas Health Science Center at Fort Worth, will examine the...
This federal Cooperative Agreement award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $1,496,003.00 in funding to The Regents of the University of California, San Francisco (UCSF) to conduct research on the brain-bone axis and its influence on skeletal health. The project aims to identify a brain-derived factor that can increase bone mass and reduce bone fat, with the goal of translating these findings to address age-related skeletal and metabolic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $205,000.00 to The Regents of the University of California, San Francisco to conduct research on pain management in the elderly. The key objectives are to: Establish whether aged rats exhibit nociceptor plasticity (hyperalgesic priming) and if this is associated with systemic inflammation. Identify the mechanisms underlying age-associated priming, including the role of mitochondrial...
The federal Project Grant award of $159,512.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Florida to investigate the role of the kynurenine pathway and aryl hydrocarbon receptor (AhR) activation in age-related physical decline and frailty. The research will use novel genetic mouse models to test if elevated levels of L-kynurenine, reduced skeletal muscle L-kynurenine degradation, and chronic AhR activation contribute to the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $416,625.00 to Saint Louis University to conduct research on the relationship between aging, sex, hormonal status, and anti-inflammatory therapy for atherosclerosis. The study aims to comprehensively map atherosclerosis-prone transcriptomic profiles at the single-cell level, focusing on inflammatory cell clusters, cell-cell communication networks, T-cell mediated dysfunction, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Francisco (UCSF) provides $123,309 in funding to study the role of fatty acid signaling in regulating translation and its impact on metabolic health during fasting and aging. The key objectives are to: 1) Identify the molecular mechanisms by which fatty acids induce specific mRNA translation, including the regulatory motifs and upstream signaling pathways, and 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $866,764 to The Regents of the University of California, San Francisco (UCSF) to conduct an interdisciplinary study on human-specific vulnerabilities and compensatory adaptations in midbrain dopaminergic neurons. The study aims to measure dynamic gene regulatory responses and candidate neuroprotective pathways in these neurons under age-related oxidative stress, using stem cell-derived...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $564,530.00 to Emory University to investigate the association between the Alzheimer's disease risk gene APOE4 and the menopause-related hormone follicle-stimulating hormone (FSH) in the initiation and progression of Alzheimer's disease, particularly in women. The research aims to explore how APOE4 may facilitate Alzheimer's pathology related to FSH-induced mechanisms, including tau...
This $1,294,013 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year clinical trial and associated research examining the impact of biological aging mechanisms on exercise response variability in older adults. The principal investigator will conduct a randomized trial of a 6-month resistance training intervention and a health education control, focusing on two co-primary outcomes: physical function and insulin sensitivity. The project will...