Project Grant R21AG089957

Award Date 8/1/24
Completion Date 7/31/26
Dollars Obligated $417K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Missouri, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $378,750 in funding to Saint Louis University to conduct research on the role of cytosolic DNA-induced sterile inflammation in driving cellular and organismal progeria/aging hallmarks. The key objectives are to: 1) define the non-canonical mode of STING stimulation upon progerin-induced accumulation of cytosolic DNA, 2) examine how STING, STAT1, and downstream interferon-stimulated genes like...
The National Institute on Aging (NIA) awarded a $1,905,716 Project Grant under CFDA 93.866 - Aging Research to New York University (NYU) School of Medicine to investigate the role of inflammation in the decline of skeletal stem and progenitor cells (SSPCs) during aging. The 5-year grant, awarded on August 1, 2024, aims to elucidate the molecular mechanisms regulating the inflammatory response in SSPCs and how anti-inflammatory factors can resolve inflammation to improve bone health and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $416,625 to Saint Louis University to conduct research on modulating the expression of longevity-associated genes using antisense oligonucleotides (ASOs). The project aims to: 1) design and test ASOs to regulate the levels of four key longevity genes, and 2) evaluate if the ASOs can extend lifespan and improve healthspan in an accelerated aging mouse model. Successful completion of this 2-year...
This $445,500 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) aims to define the mechanisms by which platelets regulate monocyte/macrophage interactions at the site of abdominal aortic aneurysm (AAA) injury. The goal is to develop new tools to harness this knowledge to support reparative tissue regeneration and de novo morphogenesis for cardiovascular damaged tissues, specifically AAA. The research will utilize unique animal models...
The National Institute on Aging has awarded a $2,541,656 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic to characterize senescent cell populations in the bone microenvironment and their contribution to skeletal aging. The research aims to leverage novel mouse models and multiparametric single-cell analysis to better define the mechanisms driving cellular senescence and identify key senescent cell populations that mediate age-related bone loss and other aging co-morbidities. As...
This $513,957 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research supports research to understand the cellular mechanisms regulating lymph node maintenance and homeostasis in aging. The study aims to determine the effects of aging on lymphatic endothelial cells (LECs) and the role of LEC NF-kB signaling in adult lymph node function. The researchers will leverage single-cell RNA sequencing and novel...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $508,368.00 to the University of Louisville to study the impact of aging on myocardial perfusion and cardiac function. The research aims to delineate age-dependent changes in cardiac metabolism, myocardial perfusion, and ventricular function, assess the role of myocardial glucose metabolism on perfusion, and evaluate metabolic interventions to mitigate age-related...
This federal Project Grant award of $437,366 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research conducted by the University of Louisville to investigate the effects of age-related changes in lipid metabolism on stem cell niche homeostasis. The research aims to understand mechanistically how the stem cell niche is impacted by the ectopic accumulation of lipids, which has been shown to be detrimental to stem cell maintenance across species. The project...
The National Institute on Aging (NIA) awarded a $227,250 Project Grant (CFDA 93.866 - Aging Research) to Saint Louis University to conduct research on the role of the protease Cathepsin L (CTSL) in regulating the nuclear proteome and its impact on cellular responses to nuclear damage and stress. The 2-year project aims to: 1) Elucidate the mechanism by which CTSL modulates the processing and function of the nuclear architectural proteins Lamin A/C, Lamin B1, and Lamin B2; 2) Investigate how...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $700,398 to conduct research on identifying new molecular and cell-specific mechanisms of atherosclerotic cardiovascular disease (CVD) plaque vulnerability. The research aims to integrate spatial transcriptomics, genetics, and histomorphology using human and mouse atherosclerotic lesion samples...

The National Institute on Aging awarded a $416,625 Project Grant (CFDA 93.866 - Aging Research) to Saint Louis University to study the effects of age, sex, and hormonal status on atherosclerotic cardiovascular disease (ASCVD). The research aims to test whether promoting an anti-inflammatory, pro-resolving environment in atherosclerotic plaques can be atheroprotective, using pulsed low-dose RANKL treatment in young and aged male and female mice. The study will comprehensively map transcriptomic profiles of atheroma-prone regions at single-cell resolution to investigate inflammatory cell clusters, cell-cell communication networks, and markers linked to plaque stability/vulnerability. This innovative discovery approach seeks to elucidate additional lipid-independent mechanisms contributing to ASCVD progression and identify novel plaque-secreted biomarkers for assessing disease severity. The award period runs from August 1, 2024 to July 31, 2026.

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