The National Institute on Aging (NIA) awarded Emory University a $564,530 Project Grant under the Aging Research federal grant program (CFDA 93.866) to investigate the associative role of the Alzheimer's disease risk gene APOE4 and the menopause-related hormone follicle-stimulating hormone (FSH) in the initiation and progression of Alzheimer's disease. The 5-year project, which commenced on December 15, 2024, will explore how APOE4 facilitates Alzheimer's pathology in women, particularly related to FSH-induced mechanisms. The research will also examine if APOE4 mediates tau propagation and microglial-induced inflammation with FSH, potentially contributing to sex-dependent Alzheimer's disease progression. Additionally, the team will test the synergistic therapeutic effect of a protective APOE3 mutation and an FSH antibody using an Alzheimer's mouse model. Successful completion of this project is expected to provide insights into novel molecular mechanisms underlying sex-dependent Alzheimer's disease progression and present a new therapeutic strategy for the intervention and prevention of the disease.
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