This federal Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $1,359,000 to Baylor College of Medicine to conduct research on cellular and molecular adaptations for whole-organism rejuvenation. The key goals of the project are to determine how age-associated damage manifests in the regenerative flatworm Schmidtea mediterranea and identify the cell types and signaling pathways that regulate cellular aging, detection of...
This Cooperative Agreement award, valued at $1,988,426.00, was granted by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The award supports research to understand inter-organ communication and biological age changes resulting from heterochronic organ transplantation - a clinically relevant model for studying how young and old cells transferred with an organ transplant may have rejuvenating or aging effects. The research team from Brigham...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $422,419 to the University of California, Los Angeles (UCLA) to investigate the molecular mechanisms underlying cellular rejuvenation through partial reprogramming. The goal is to map changes in the transcriptome, chromatin landscape, transcription factor binding, and epigenetic age across the partial reprogramming process using the OSKM transcription factors. This research aims to identify...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $1,404,000.00 to the Regents of the University of Michigan to investigate the molecular and cellular mechanisms behind age reversal in the planarian species Schmidtea mediterranea. The goal is to identify evolutionarily conserved genes and epigenetic regulators that could contribute to anti-aging therapies in humans. The research will examine asymmetrical age...
Duke University has been awarded a $4,537,430 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, to support research under the Aging Research program (CFDA 93.866).
The grant will fund a study from September 2022 to August 2025 to examine the role of cellular senescence on postoperative neuroinflammation. Specifically, the researchers will use a mouse model of orthopedic fracture to determine how senescent cell burden exacerbates systemic...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to...
This $402,500 federal Project Grant award from the National Institute on Aging (NIA), CFDA 93.866 Aging Research program, supports research at Duke University on the role of glutamine metabolism in regulating muscle stem cell function. The key objectives are to: 1) Test if glutamine-driven "bidirectional" metabolism, including both oxidative and reductive pathways, is necessary for muscle stem cell function and myogenesis; 2) Determine if glutamine metabolism is impaired in aged...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets;...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will support research to develop metabolomics-based biomarkers, or "clocks", as tools to explore mechanisms of aging. The $592,507 award to Tufts University School of Medicine, with a period of performance from Sep 30, 2024 to Jun 30, 2029, will fund the development of sex- and tissue-specific metabolome clocks in the Drosophila model organism. The research aims to use these...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $700,808 in funding to President and Fellows of Harvard College to conduct research on the role of age-related changes in blood cells as a potential driver of dysfunction in other organ systems, such as the cardiovascular, neurological, and skeletal muscle systems. The project aims to use novel in vivo gene editing techniques to introduce specific somatic mutations associated with...