This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related disease. Experiments will test whether interventions like dietary restriction remodel protein cysteine oxidation networks to promote longevity. Additionally, Harvard T.H. Chan School of Public Health will carry out complementary experiments utilizing the aging model C. elegans to define causal effects of redox modifications on aging and healthspan, and examine effects of altered metabolism on longevity. Outcomes will provide new mechanistic insights into redox regulation over the lifespan and its influence on aging.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 8/12/22 | ||
| Not listed | $0 | 8/12/22 | ||
| Not listed | $343.9k | 4/14/21 | ||
| Not listed | $343.9k | 4/14/21 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
PO1382194S | President And Fellows Of Harvard College | Project Grant R56AG071966 | $47.2k | 4/15/21 |