Project Grant R21AG085245
Award Date
9/15/24
Completion Date
6/30/26
Dollars Obligated
$233K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
Similar Awards
This $4.46 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866) to develop a new in vivo magnetic resonance imaging biomarker for early detection of Alzheimer's disease neurodegeneration. Specifically, the awardee, Washington University, will utilize quantitative gradient recalled echo MRI techniques to identify two types of hippocampal tissue in preclinical and mild...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a pilot study to evaluate the feasibility of using non-invasive neuroimaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease (AD). The $332,096 award, with a performance period from July 2024 to June 2026, will be made to The General Hospital Corporation (doing business as Massachusetts General Hospital). The research...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,969,644 to develop a novel positron emission tomography (PET) imaging probe targeting myeloperoxidase (MPO) activity for detecting neuroinflammation in neurodegenerative diseases. The Massachusetts General Hospital will design and screen potential PET agents for detecting MPO activity in the brain, characterize and validate candidate MPO PET...
This $497,196 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a novel magnetic resonance spectroscopic imaging (MRSI) pulse sequence at 3 Tesla. The goal is to simultaneously map both downfield and upfield proton metabolic signals in the human brain, which may provide important new insights into brain metabolism....
The National Institutes of Health National Institute on Aging awarded $4,575,712 under the Aging Research program (CFDA 93.866) to The Washington University from May 2022 to April 2025. The award will support research into white matter metabolism in the context of aging, white matter hyperintensities, and Alzheimer's disease. Investigators will apply quantitative positron emission tomography imaging techniques to measure cerebral oxygen consumption, blood flow, oxygen extraction fraction, and...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $185,625 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop a novel magnetic resonance imaging (MRI) excitation technique. The project aims to address the flip angle inhomogeneity problem in high-field 7 Tesla MRI...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop advanced MRI techniques to directly assess cerebral microvascular pulsatility on widely available 3T MRI systems. The $4,692,540 award to Northwestern University will fund research to evaluate cerebral microvascular pulsatility as a potential biomarker for cerebral small vessel disease (CSVD), which is a major contributor to strokes and dementia. The project, running from August 2024 to...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under CFDA Program 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health", supports the development of a fast, comprehensive brain MRI technique. The $884,573 award aims to create an 8-minute brain MRI exam that captures a variety of quantitative and qualitative MRI contrasts, as well as time-resolved gadolinium-based enhancement, in order to...
This Project Grant award of $812,030, awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, aims to develop and optimize non-invasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The key products and services to be delivered include: Investigating the relationship between astrocytic acetate metabolism and astrocyte reactivity in an AD model using deuterium-based magnetic resonance spectroscopy...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Neuroscope Inc. in the amount of $1,193,370 aims to develop a computational toolset for mapping and quantifying perivascular space (PVS) morphology from MRI. The goal is to create a non-invasive, automated method to assess PVS, which is an important diagnostic feature for Alzheimer's disease and vascular dementia. The funded work will build the IT infrastructure to commercialize Neuroscope's PVS...